The many clues on the setting suggest the location was set in the era of the great depression in the USA. For example, Lennie and George carry their bed rolls and indicate that they do not have a permanent location to stay and sleep at showing that many of them were not very wealthy. Also jobs offered are very temporary as George and Lennie leave one job to another and are not usually permanent as employment was also scarce in the Great Depression. There was also very little transportation during that time as George and Lennie cannot get far enough into their location and have to walk. Eventually when George and Lennie arrive in the pristine natural environment it appears like the Garden of Eden. The area sounds like paradise with rabbits and wildlife giving it full of hope and thus the readers are uplifted. Yet, he does this specifically because he wants them to fall at such a height in order to show the fall of Adam and Eve in the Garden of Eden.
The protagonists of the story are George and Lennie and could be likened to Adam and Eve. You could say this because Eve was very innocent like Lennie while Adam was dragged into doom because of Eve like Lennie and George in the final chapter. Furthermore, their personalities heavily contrast as George appears as careful, wary and thin while Lennie is clumsy, large and innocent. Yet, while together they appear as a symbiotic relationship and always work together as George is used to get away
Bibliography: parknotes.comOf Mice and Men by John Steinbeck