Doxorubicin Research Paper

Doxorubicin is a secondary metabolite produced by sterptomyces peucetius var.caesius and belongs to ANTs (2). Doxorubicin is an efficient anti-neoplaastic agent used for treatment of child and adult cancers such as solid tumors, leukemia, lymphoma and breast cancer (2). Optimal administration of doxorubicin is hampered due to some toxicity such as hematopoietic suppression, nausea, vomiting, extravasation, alopecia and cardiotoxicity (2). Cytotoxic chemotherapy-induced cardiotoxicity has a high incidence (2). Cardiotoxicity includes short- and long-term toxic effects in the heart including alterations in mayocardial structure and function to severe cardiomyopathy and heart failure that may result in heart transplantation or death. Chronic cardiotoxicity