Preview

Effect Of Lycopene On Leukoplakia

Powerful Essays
Open Document
Open Document
1812 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
Effect Of Lycopene On Leukoplakia
Abstract:
Need for the study: Oral precancerous lesions are one of the most prevalent lesions worldwide today. Leukoplakia is the commonest premalignant lesion , which if neglected can be fatal. Several therapeutic agents have been tried to intervene. Of which, Lycopene has been tried, tested and accepted as a conventional form of treating leukoplakia. Curcumin, 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6- heptadiene-3,5-dione] is regarded as the most biologically active constituent of the spice turmeric consisting 2–8% of most turmeric preparations. It has anti-oxidant, anti-inflammatory and and pro-apoptotic activities. The purpose of the study was to compare the anti-precancerous activities of lycopene with curcumin. Methodology: A randomized
…show more content…
The informed consent of the patients was obtained before the trial after briefing them about the risks and benefits of the study. The patients were taken into the study based on the following eligibility criteria. Inclusion criteria was the presence of clinically and histopathologically diagnosed leukoplakia, those who had not taken any form of treatment for leukoplakia in the last 6 months, patients with willingness to quit the adverse habits(smoking tobacco, chewing tobacco and alcohol) and those who were ready for a 6 months follow up. Patients with any systemic diseases, who are already diagnosed with carcinoma and pregnant and lactating mothers were excluded. A proforma was filled which elicited a thorough personal history, habits history and dental history.
Patients were randomly allocated into either of the two groups. A double blind study was undertaken to minimize any bias occurring in the association of cause and effect. The patients and the analyst were not informed as to which group they belonged.
Group A (Curcumin group): 10 patients were given with 1g of curcumin capsules orally in 2 divided doses daily for a period of three
…show more content…
The mean size of the lesion in Group A was 17.544, while the Group B mean size of the lesion was 17.503before treatment. The Group A mean size of the lesion was 3.12, while the Group B mean size of the lesion was 2.763 after treatment. (Table 3 and 4)The t test value at p level lesser than 0.0001 and degrees of freedom at 9 for Group A is 15.614, which shows there is a significant improvement with curcumin therapy. The t test value at p level lesser than 0.0001 and degrees of freedom at 9 for Group B is 13.48 ,which depicts a significant improvement of the lesion with lycopene therapy. It can be noted that the size of the lesion reduced drastically both in the study and control group, suggesting that curcumin had equivalent tumor suppressing property as that of lycopene. (Table

You May Also Find These Documents Helpful

  • Satisfactory Essays

    Exercise 29 Statistices

    • 973 Words
    • 4 Pages

    Were the groups in this study independent or dependent? Provide a rationale for your answer.…

    • 973 Words
    • 4 Pages
    Satisfactory Essays
  • Satisfactory Essays

    Lycopene Research Paper

    • 436 Words
    • 2 Pages

    Studies have shown that lycopene is also effective in fighting many diseases such as cancer as well as cardiovascular conditions.…

    • 436 Words
    • 2 Pages
    Satisfactory Essays
  • Satisfactory Essays

    Anna K Leon is not a medical practitioner and do not diagnose, treat or prescribe in any shape, manner or form. Always discuss with your medical practitioner before using any alterNative medicines, natural supplements, or vitamins. My daughter motivated me to get involved with oils, I first started using it and then I experienced some great benefits. I signed up with her group but I continued to buy through my daughter. It is kindof expensive for me but I enjoy the oils. All information, content and product descriptions contained within this book are for reference purposes and are not intended to substitute advice given by a pharmacist, physician or other licensed health-care professional. You should not use this information…

    • 313 Words
    • 2 Pages
    Satisfactory Essays
  • Powerful Essays

    References: Ferniany, W. (2008). UAB Medicine [Causes of Skin Cancer]. Retrieved August 3, 2009, from http://www.health.uab.edu…

    • 2196 Words
    • 9 Pages
    Powerful Essays
  • Good Essays

    The effect of lycopene on 7,12 dimethyl benz(a)anthracene (DMBA) induced experimental breast cancer was investigated in female Sprague Dawley rats. Histopathological examination revealed the formation of tumor and angiogenesis in DMBA-induced rats and these abnormal changes were ameliorated by treatment with lycopene. The protective effect of lycopene was inherent to the increase of the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)) and glutathione (GSH). Flux cytometry and gene expression analyses indicated that lycopene inhibits breast tumorigenesis by promoting apoptosis in mammary tissue through the mediation of pro- and anti-apoptotic biomarkers. Further analyses suggested that the antitumor…

    • 145 Words
    • 1 Page
    Good Essays
  • Good Essays

    The limitations in this study could be that the control group and the study group came from two (2) separate studies that were conducted at different times. Another limitation to be considered was that this study was only conducted at the Royal Melbourne…

    • 672 Words
    • 3 Pages
    Good Essays
  • Better Essays

    And the perturbation group had 11 successful subjects and 1 unsuccessful. With a p value of = .05 it was shown that a significant number of patients where unsuccessful in the standard group compared to the perturbation group. Even with the small numbers used in this study shows a significant number of patients being successful in the perturbation group compared the standard group a difference of 50% success rate in the standard group and 91% in the perturbation group. (Fitzgerald, Axe, & Snyder-mackler, 2000)…

    • 1645 Words
    • 7 Pages
    Better Essays
  • Best Essays

    Autism Technical Report

    • 4034 Words
    • 17 Pages

    determine a link between the two. Although no definitive correlation has been made, research is…

    • 4034 Words
    • 17 Pages
    Best Essays
  • Better Essays

    JAMA: The Journal of the American Medical Association Issue: Volume 285(20), 23/30 May 2001, pp 2622-2628…

    • 1151 Words
    • 5 Pages
    Better Essays
  • Better Essays

    Payne, R. A. (2010). Payne 's handbook of relaxation techniques a practical guide for the…

    • 1372 Words
    • 6 Pages
    Better Essays
  • Better Essays

    Earplugs

    • 1038 Words
    • 5 Pages

    To explain, informed consent was obtained from all participants of the study and they were individually informed by a researcher. The authors claimed that all data collected was made anonymous. They also note that they received approval for the study from Antwerp University Hospital’s board of ethics before beginning in November and additionally registered the trial in the Current Controlled Trials database. The authors provided reference numbers for both the ethics board approval and the trial…

    • 1038 Words
    • 5 Pages
    Better Essays
  • Satisfactory Essays

    John W Cherry

    • 4229 Words
    • 17 Pages

    Research on Cancer (IARC) as known or probable human carcinogens (Groups 1 and 2a, respectively). In…

    • 4229 Words
    • 17 Pages
    Satisfactory Essays
  • Good Essays

    Critical Appraisal Paper

    • 1796 Words
    • 8 Pages

    (2) Yes, the abstract succinctly describes the purpose of the clinical investigation posed in the paper, the patients and methods used for the investigation, the results, and the conclusions. Yes, the purpose, patients and methods, results, and conclusions, provided in the abstract, are with adequate details. The purpose briefly mentions what is the subject of the investigation and why it has done; the patients and methods concisely informs who were the patients and what methods were used; the results summarizes the most important results obtained; the conclusions succinctly notes what the results mean and how these outcomes can…

    • 1796 Words
    • 8 Pages
    Good Essays
  • Satisfactory Essays

    Epidemiologic research encompasses several types of study designs, including experimental studies and observational studies. Each type of epidemiologic study design simply represents a different way of gathering and interpreting information. The selection of one design over another depends on the particular research question, concerns about validity and efficiency, and practical and ethical considerations. Most researchers prefer case control study design over other study designs. Case-control is a type of epidemiological, clinical study design. It is typically used for retrospective studies. In a case-control study, people with a disease (often, a specific diagnosis, perhaps lung cancer) are matched with people who do not have the disease (the 'controls'). Further data are then collected on those individuals and the groups are compared to find out if other characteristics (perhaps a history of smoking) are also different between the two groups. According to Mosby's Medical Dictionary, (8th edition 2009) a case-control study is a nonexperimental research design using an epidemiologic approach in which previous cases of the condition are used in lieu of new information gathered from a randomized population. A group of patients with a particular disease or disorder, such as myocardial infarction, is compared with a control group of persons who have not had that medical problem. The two groups, matched for age, sex, and other personal data, are examined to determine which possible factor (e.g., cigarette smoking, coffee drinking) may account for the increased disease incidence in the case group. Case control studies are more preferred by the researchers or investigators due to a lot of reasons. Let’s talk about a few of the advantages of the case control study  Rapid and easy to carry out  Economic  Comparatively few subjects are required  No risk to subjects  Risk factors can be identified  Minimal or no ethical issues…

    • 538 Words
    • 3 Pages
    Satisfactory Essays
  • Good Essays

    The fruit is an excellent source of Vitamin A, (100 g provides 3382 IU or about 112% of recommended daily levels) one of the highest among cucurbita fruits. Vitamin A is a powerful antioxidant and is essential for healthy vision. It is also required for maintaining healthy mucus membranes and skin. Consumption of natural fruits rich in vitamin A has been known to help protect from lung and oral cavity cancers.…

    • 804 Words
    • 4 Pages
    Good Essays