Essay On Dysfunctional Pruning
Anete Miljkovic
Popular Science 1
Autism caused by dysfunctional synaptic pruning?
Research shows that autism patients have an increased number of synapses, leading to a slower and less efficient neuronal communication. Due to dysfunctional pruning mechanism, the brain fails to weed out the unnecessary synapses resulting in autism like symptoms.
Autism is a complicated multifactorial disorder Autism is a collection of many diseases and it has many genetic causes. Examined brains of children and adolescents with autism and controls and found that there is a difference. Fro mearly childhood into adolescence synapses – the measn of communication – are pruned. This doesn’t occur in people in autism. The next question is why? There …show more content…
This was caused by a faulty pruning mechanism, where an overactive protein interferes with the brain’s pruning. The protein is known as mTOR and found in large amounts in autistic brains.
Pruning is a process designed to eliminate unnecessary neuronal connections to make for a faster and more efficient communication. Research done by Tang G. et al (2014), indicate that dysfunctional brain pruning might contribute to Autism Spectrum Disorders.
Previous research has indicated that ASD brains contain abnormalities in spine density in frontal, temporal and parietal lobes.
This finding provides a new look on autism therapy. It is possible that in future autism and autism-like disorder might be treated by mTOR inhibitors.
It is possible to use this mechanism in treatment. Can replicate ir chemically by using a dug which increase autophagy, thus synaptic pruning. Even after child is diagnosed, it is not too late and might be treatable.
It is also plausible hat pruning may be involved in other psychiatric disorders. This research can pave the way for new treatments for those with autism or autism like symptoms.
Higher concentrations of TOR protein in autism
Popular Science 1
Autism caused by dysfunctional synaptic pruning?
Research shows that autism patients have an increased number of synapses, leading to a slower and less efficient neuronal communication. Due to dysfunctional pruning mechanism, the brain fails to weed out the unnecessary synapses resulting in autism like symptoms.
Autism is a complicated multifactorial disorder Autism is a collection of many diseases and it has many genetic causes. Examined brains of children and adolescents with autism and controls and found that there is a difference. Fro mearly childhood into adolescence synapses – the measn of communication – are pruned. This doesn’t occur in people in autism. The next question is why? There …show more content…
This was caused by a faulty pruning mechanism, where an overactive protein interferes with the brain’s pruning. The protein is known as mTOR and found in large amounts in autistic brains.
Pruning is a process designed to eliminate unnecessary neuronal connections to make for a faster and more efficient communication. Research done by Tang G. et al (2014), indicate that dysfunctional brain pruning might contribute to Autism Spectrum Disorders.
Previous research has indicated that ASD brains contain abnormalities in spine density in frontal, temporal and parietal lobes.
This finding provides a new look on autism therapy. It is possible that in future autism and autism-like disorder might be treated by mTOR inhibitors.
It is possible to use this mechanism in treatment. Can replicate ir chemically by using a dug which increase autophagy, thus synaptic pruning. Even after child is diagnosed, it is not too late and might be treatable.
It is also plausible hat pruning may be involved in other psychiatric disorders. This research can pave the way for new treatments for those with autism or autism like symptoms.
Higher concentrations of TOR protein in autism