(2+1)
In fermentation industry, various commercial products of important economic value made by microorganisms are (1) pharmaceuticals, including antibiotics, steroids, human protein, vaccines, and vitamins; (2) organic acids; (3) amino acids; (4) enzymes; (5) organic solvents; and (6) synthetic fuels. Some Microbial Species Used for Producing Commercial Products. Industrial Chemicals Saccharomyces cerevisisae Ethanol (from Kluyveromyces fragilis glucose) Clostridium Ethanol (from acetobutylicum lactose) Asergillus niger Acetone and Butanol Citric acid Amino Acids and Flavor-enhancing Nucleotides Corynebacterium L-Lysine glutamicum 5'- inosinic acid and Corynebacterium 5' – guanylic acid glutamicum MSG Corynebacterium gluatamicum Vitamins Ashbya gossypii Raboflavin Eremothecium ashbyi Riboflavin Pseudomonas denitrificans Vitamin B12 Propionibacterium Vitamin B12 shermanii Bacillus brevis Bacillus subtilis Bacillus polymyxa Rhizos nigricans Arthrobacter simplex Mycobacterium Escherichia coli (via recombinant DNA technology) Polysaccharides Dextran Xanthan gum
Leuconostoc mesenterioes Xanthomonas campestris
Pharmaceuticals Penicillum chrysogenum Cephalosporium acremonium Streptomyces Penicillins Cephalosporins Amphotericin B, kanamycins, Neomycins, streptomycin, Tetracyclines and others Gramicidin 5 Bacitracin Polymyxin B Steroid transformation Steroid transformation Steroid transformation Insulin, human growth bormone, somatostain, interferon
Enzymes Aspergillus oryzae Amylases Asergillus niger Glucamylase Tricholderma reesii Cellulase Saccharomyces cerevisiae Invertase Kluyveromyces fragilis Lactase
Saccharomycopsis lipolytica Asergillus Bacillus Mucor pussilus Mucor meihei
Lipase Pectinases and proteases Proteases Microbial rennet Microbial rennet
Generally, three are two or three methods of culturing microorganisms on large scale. These are: (i) surface culture method, (ii) submerged culture method and (iii)