Glucose Metabolism
Sir Safar Lecture 2 Finals
Pentose Phosphate Pathway (S. 70)
Alternative pathway for glucose oxidation.
Similar to glycolysis, but instead of having pyruvate as the end product it is diverted to other pathways.
Supplier of energy to the cell in the form of NADPH (a reducing power for biosynthesis).
It is also referred to as hexose monophosphate shunt.
*Fate of glucose 6-phosphate (G 6-P) IN THE PPP (S. 71)
Taken out from glycolysis and converted into Ribulose 5-phosphate.
With the conversion of ribulose 5-phosphate 2 moles of NADPH acquired protons from glucose 6-phosphate.
Glucose 6-phosphate is oxidized and converted into ribulose 5-phosphate, having the removed protons from Glucose 6-phosphate is transferred to NADP which soon becomes NADPH.
NADPH is accumulated and later used for biosynthesis.
*Fate of Ribulose 5-phosphate
Ribulose 5-phosphate can now proceed to different enzymatic reactions.
It is acted by an enzyme (Not specified) and converting it into ribose 5-phosphate.
Oxidizing it and making it into ribose 5-phosphate.
Ribulose 5-phosphate and xylulose 5-phosphate can later be converted into carbohydrate intermediates (fructose 6-phosphate) which are present in glycolysis.
*Main Points in the pentose phosphate pathway (S. 72)
G-6-P shunted to PPP
PPP leads to production of NADPH and Ribose sugar (ribose 5-phosphate )
NADPH is utilized in many biosynthetic pathway (ex. Synthesis of UFA’s, cholesterol, Amino Acids and Ribose Reduction in the objective of making ribose sugar).
In plant systems is used in photosynthesis.
Ribose sugar serves as a sugarmoeties in RNA if reduced is made to Deoxyribose
RBCs utilize PPP for retaining the Hemoglobin molecule in the reduced state by generating antioxidant glutathione.
Hemoglobin goes under wear and tear state because of its degree of importance.
Hemoglobin needs repair on a regular basis.
PPP is the pathway for the repair of Hemoglobin through the production of antioxidants.
*Glycolysis Map (S.
Pentose Phosphate Pathway (S. 70)
Alternative pathway for glucose oxidation.
Similar to glycolysis, but instead of having pyruvate as the end product it is diverted to other pathways.
Supplier of energy to the cell in the form of NADPH (a reducing power for biosynthesis).
It is also referred to as hexose monophosphate shunt.
*Fate of glucose 6-phosphate (G 6-P) IN THE PPP (S. 71)
Taken out from glycolysis and converted into Ribulose 5-phosphate.
With the conversion of ribulose 5-phosphate 2 moles of NADPH acquired protons from glucose 6-phosphate.
Glucose 6-phosphate is oxidized and converted into ribulose 5-phosphate, having the removed protons from Glucose 6-phosphate is transferred to NADP which soon becomes NADPH.
NADPH is accumulated and later used for biosynthesis.
*Fate of Ribulose 5-phosphate
Ribulose 5-phosphate can now proceed to different enzymatic reactions.
It is acted by an enzyme (Not specified) and converting it into ribose 5-phosphate.
Oxidizing it and making it into ribose 5-phosphate.
Ribulose 5-phosphate and xylulose 5-phosphate can later be converted into carbohydrate intermediates (fructose 6-phosphate) which are present in glycolysis.
*Main Points in the pentose phosphate pathway (S. 72)
G-6-P shunted to PPP
PPP leads to production of NADPH and Ribose sugar (ribose 5-phosphate )
NADPH is utilized in many biosynthetic pathway (ex. Synthesis of UFA’s, cholesterol, Amino Acids and Ribose Reduction in the objective of making ribose sugar).
In plant systems is used in photosynthesis.
Ribose sugar serves as a sugarmoeties in RNA if reduced is made to Deoxyribose
RBCs utilize PPP for retaining the Hemoglobin molecule in the reduced state by generating antioxidant glutathione.
Hemoglobin goes under wear and tear state because of its degree of importance.
Hemoglobin needs repair on a regular basis.
PPP is the pathway for the repair of Hemoglobin through the production of antioxidants.
*Glycolysis Map (S.