Gm Pigs Xenotransplantation

The possible role of genetically modified pigs in xenotransplantation.

Table of contents

Abstract. …......................................................................................................... Page. 4

2. Introduction. ..................................................................................................... 5-7

3. The possibilities for creating genetically modified pig donor organs.

3.1. The genetic modification of pigs for the purpose of xenotranplantation. ........ 8

4. Review of techniques used by researchers to genetically modify pigs for the purpose of xenotransplantation. ............................................................................................... 4.1. Sperm mediated gene transfer ............................................................ 9 4.2. Somatic cell nuclear transfer ............................................................ 10

5. Overcoming the immunological barriers to xenotransplantation.
5.1. Hyperacute rejection ….................................................................................. 11-12
5.2 Acute humoral xenograft rejection …............................................................ 13-14

6. Risk assessment – Possibility of porcine endogenous retrovirus crossing the pig to human species barrier.
6.1. The possible risk of xenotic infection............................................................. 15-16
6.2. Strategies to minimize xenotic infection. ....................................................... 17

7. Communicating the possible risk of transmissible xenotic disease to the public.

7.1. Communication, and the methods of communicating risk. ............................ 18

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