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Hepatopulmonary Syndrome Research Paper

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Hepatopulmonary Syndrome Research Paper
The liver is a vital organ within the human body. The normal pathophysiology of the liver is to perform critical functions which rid the body of harmful toxins and substances. The liver rids the body of its harmful toxins by the way it secretes chemicals and produces bile. Bile is a substance that helps the breakdown of lipids and salts so that they are easily absorbed into the intestine to be secreted out of the body.
Vasodilators are medications which cause the blood vessels within the human body to dilate. Vasodilators just don't affect the vessels, but also the muscles and the walls of veins and arteries within the human body. Vasodilators are used to prevent the muscles in the body from tightening which allows easy blood flow throughout
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An increase in the heart rate and cardiac output occurs which dilates the blood vessels causing the blood to flow throughout the liver more efficiently. (Schwartz JS, 1987)
Hepatopulmonary syndrome (HPS) is caused by liver disease, HPS occurs from the vasodilation of the blood vessels. When vasodilation occurs it causes a shortness of breath due to the exertion and loss of energy, and it also causes hypoxaemia which is due to vasodilation. (Spagnolo, Zeuzem, Richeldi, & Bois, 2010) In saying this pulmonary vasodilation occurs during liver failure due to being mediated by many different endogenous vasoactive molecules such
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Q or perfusion is the blood flow of deoxygenated blood from the heart. This blood flows through the pulmonary arteries and into the capillary beds. This is where oxygen and nutrient exchanges take place
With that explained it tells us that alveoli are the smallest airways and that capillaries are the smallest blood vessels within the human body. They also both are only one cell thick. Within Ventilation/perfusion mismatch, the oxygen from the alveoli transfers to the capillaries and then the carbon dioxide from the capillaries transfers to the alveoli and this is what is measured. The amount of air the reaches the alveoli which are then divided by the amount of blood which flows through the capillaries.
So now we can understand that V/Q mismatch is the areas within the lungs where the alveoli's and capillaries do not line up which is also called the dead space. This just shows that the lungs aren't the same throughout. Some parts of the lungs are more perfused where others are more ventilated.
The equation for Ventilation/perfusion mismatch

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