Preview

Hypp

Good Essays
Open Document
Open Document
735 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
Hypp
Summer Churchill

Not So Impressive

On the morning of July 19th, Jenny was enjoying a ride on her 17 year old quarter horse mare Dottie. The pare loped leisurely around short side of the arena, when suddenly, Dottie’s head dropped and she seemed to suck back in an effort to prevent herself from falling. Within moments both jenny and Dotty crashed to the ground. Described by witnesses as “the worst crash they’d ever seen”, Jenny was rushed to the emergency room with her shoulder fractured in two places (Ruldolph, JA). While most horse people will agree, accidents do occur, something seemed different about this particular incident. What actually went wrong? For weeks following after, Dottie still seemed off in her behavior. Some days she would be normal, but on others she would lose her appetite and seemed to struggle to stay on her feet. Even after being examined by several veterinarians who passed the mares strange behavior as episodes of colic, Dottie’s condition fail to improve. Finally a local vet suggested testing for a disease called Hyperkalemic Periodic Paralysis. Dottie’s results came back positive.
But what is HYPP exactly? In short, it is a genetic disease found in quarter horses that affects the sodium channels. These sodium channels are pores in the muscles and when affected by the disease, do not seal properly causing potassium levels in the blood to be high. This causes the muscles to contract involuntarily (Tufts). The results can be anywhere from mild ripples, to full muscular paralyses anywhere in the body. HYPP is a disease that traces back to a genetic mutation that traces back to the champion quarter horse stallion Impressive.
In the average equine, the sodium channels are used to regulate the potassium level within the muscle cells and the sodium content in the bloodstream. Because of the imbalance between these two electrolytes, an electrical charge is created. When the sodium channels open, potassium is released into the blood



Cited: "Cummings School of Veterinary Medicine at Tufts University." Hyperkalemic Periodic Paralysis :. N.p., n.d. Web. 10 Dec. 2012. Rudolph, JA. "Hyperkalemic Periodic Paralysis Disease ( HYPP )." Hyperkalemic Periodic Paralysis Disease ( HYPP ). N.p., n.d. Web. 10 Dec. 2012. Selnow, Les. "HYPP: Hyperkalemic Periodic Paralysis." TheHorse.com. N.p., n.d. Web. 10 Dec. 2012.

You May Also Find These Documents Helpful

  • Satisfactory Essays

    The Neuromuscular junction uses synapses to connect the muscular system with the muscular system. A nerve impulse is sent from the brain down to the motor neuron by way of the axon. Acetylcholine is released after the vesicles break open. Sodium channels are opened from Acetylcholine that bonds to the Acetylcholine receptors. Depolarization happens when Acetylcholine causes an area of the muscle fiber to become a little more positive when it leaves the nerve and docks on receptors in the muscle membrane. Large amounts of Na+ ions enter the muscle fiber because channels open after depolarization, and an action potential then spreads throughout the muscle fiber. The thick and thin filaments of the muscle fiber can then contract…

    • 504 Words
    • 3 Pages
    Satisfactory Essays
  • Good Essays

    Ap Biology Muscle Cells

    • 305 Words
    • 2 Pages

    When muscle cells begin to repolarize, first the acetychloine is removed from the receptors on the cells. This in turn causes the receptor mediated Na+ leak channels to close. Voltage gated potassium leak channels open as a result. As K+ ions begin coming into the cytoplasm to repolarize. When the membrane potential reaches a specific level, the voltage gated potassium leak channels close as well. The sodium potassium pump works throughtout this process, by pumping Na+ ions out and K+ ions into the cells (using ATP, by a process called active transport).Ca2+ ions are pumped back into the SR by means of active transport. The membrane potential is then restored to the resting potential of…

    • 305 Words
    • 2 Pages
    Good Essays
  • Powerful Essays

    Nu-545 Unit 1

    • 5488 Words
    • 22 Pages

    “(3) Specific enzymes that drive active pumps that promote concentration of certain ions, particularly potassium (K+), within the cell while keeping concentrations of other ions, for example sodium (Na+), below concentrations found in the extracellular environment…” (McCance &Huether, pg. 12).…

    • 5488 Words
    • 22 Pages
    Powerful Essays
  • Good Essays

    Neuron Worksheet

    • 516 Words
    • 3 Pages

    Latoria is horseback riding when she falls and hits her head. After the accident, she has difficulty performing finely coordinated movements. Latoria has most likely damaged her…

    • 516 Words
    • 3 Pages
    Good Essays
  • Good Essays

    Haarp

    • 749 Words
    • 3 Pages

    Although the actions of Abdulrahman Zeitoun were very demoralizing and very disgusting I do not believe that his actions should delegitimize the book at all. In my opinion I believe this only strengthened the legitimacy of Zeitoun’s book.…

    • 749 Words
    • 3 Pages
    Good Essays
  • Good Essays

    KimCaseStudy 35mos

    • 2730 Words
    • 13 Pages

    significant spasticity. The history of seizure activity has resolved and Kim no longer takes medication.…

    • 2730 Words
    • 13 Pages
    Good Essays
  • Satisfactory Essays

    Als Case Study

    • 255 Words
    • 2 Pages

    Within two years, the patient became severely disabled because of generalized weakness. She experienced no sensory problems, intellectual deterioration or skin breakdown in spite of her degree of immobility. Difficulty in swallowing necessitated the use of a gastrostomy tube for feeding. The patient died of respiratory failure approximately three years after reporting the initial symptoms.…

    • 255 Words
    • 2 Pages
    Satisfactory Essays
  • Good Essays

    Hypokalemic periodic paralysis is a rare, autosomal dominant channelopathy characterized by muscle weakness or paralysis with a matching fall in potassium levels in the blood (primarily due to defect in a voltage-gated calcium channel). In individuals with this mutation, attacks often begin in adolescence and are triggered by strenuous exercise followed by rest, high carbohydrate meals, meals with high sodium content, sudden changes in temperature, and even excitement, noise or flashing lights. Weakness may be mild and limited to certain muscle groups, or more severe full body paralysis. Attacks may last for a few hours or persist for several days. Recovery is usually sudden when it occurs, due to release of potassium from swollen muscles as they recover.…

    • 426 Words
    • 2 Pages
    Good Essays
  • Satisfactory Essays

    There are several symptoms for Hypokalemic Periodic Paralysis (HYPP), such as, muscle stiffness, permanent/partial paralysis, permanent immobility, debility of a limb, and irregular heartbeat. A paralysis attack can occur at any moment without enough time of warning which leads to several falls and severe injuries. These episodes are commonly short and should last a couple hours. Longer episodes should be over within two hours after the start of the symptoms.…

    • 279 Words
    • 2 Pages
    Satisfactory Essays
  • Good Essays

    There are more than a couple of genetic disorders which disrupt normal functioning of ion channels and have disastrous consequences for the organism and the human being. Genetic disorders of ion channels and their modifiers are known as channelopathies. I am going to discuss only two genetic diseases. The Equine hyperkalemic periodic paralysis as well as human hyperkalemic periodic paralysis (Hyper PP) are caused by a defect in voltage-dependent sodium channels. It is an inherited autosomal dominant disorder that affects sodium channels in muscle cells and the ability to regulate potassium levels in the blood. Gamstorp episodic adynamy. It is characterized by muscle hyper excitability or weakness which, exacerbated by potassium, heat or cold,…

    • 246 Words
    • 1 Page
    Good Essays
  • Powerful Essays

    Wound Management

    • 1201 Words
    • 5 Pages

    Cooper, E.Mullineaux and Turner, 2011. Bsava Textbook of Veterinary Nursing 5th edition. Gloucester, British Small Animal Veterinary Association, 1994.…

    • 1201 Words
    • 5 Pages
    Powerful Essays
  • Better Essays

    Adult Health History

    • 3339 Words
    • 14 Pages

    |Neurological System (headaches, head injuries, dizziness, convulsions, tremors, weakness, numbness, tingling, difficulty speaking, difficulty |…

    • 3339 Words
    • 14 Pages
    Better Essays
  • Good Essays

    Sodium Intake

    • 958 Words
    • 4 Pages

    Sodium (Na) is the predominant cation in extra cellular fluid and its concentration is under tight homeostatic control. Excess dietary sodium is excreted in the urine. The kidney very efficiently reabsorbs the mineral when intakes are low or losses are excessive. Sodium consort with potassium, the chief cation of intracellular fluid, to maintain proper body water distribution and blood pressure. Sodium also is important in maintaining the proper acid-base balance and in the transmission of nerve impulses.…

    • 958 Words
    • 4 Pages
    Good Essays
  • Good Essays

    Circulatory Disorders- Dvt

    • 1116 Words
    • 5 Pages

    Almost anyone can contract DVT but there are factors which can significantly increase someone’s chances of developing the condition, especially if someone has one or more of these risk factors at the same time.…

    • 1116 Words
    • 5 Pages
    Good Essays
  • Good Essays

    Major causes are stroke, trauma, poliomyelitis, amyotrophic lateral sclerosis (ALS), botulism, spina bifida, multiple sclerosis, and Guillain-Barré syndrome. Temporary paralysis occurs during REM sleep, and dysregulation of this system can lead to episodes of waking paralysis. Drugs that interfere with nerve function, such as curare, can also cause paralysis. Many causes of this are varied, and could also be unknown.…

    • 1278 Words
    • 6 Pages
    Good Essays