Interleukin-8 Il-6

Cytokines are extracellular signaling proteins formed by various cells types in the body. Interleukin-6 (IL-6) is a proinflammatory cytokine and lymphokine. IL-6 is produced by almost all different types of lung cells including endothelial cells, airway epithelial cells, fibroblasts, and, most notably, alveolar macrophages. IL-6 is thought to play a role in all types of acute lung inflammation through its stimulatory effects on lymphocytes and the acute phase response. Interleukin-8 (IL-8), a CXC chemokine, is an important neutrophil chemoattractant and activator. Tumor necrosis factor-alpha (TNF-α) is also proinflammatory cytokine. These cytokines have been shown to be important markers of inflammation and play key roles in the persistence