Isolation of Trimyristin from Nutmeg
Isolation of Trimyristin from Nutmeg by Extraction
Introduction:
Extraction is the physical process by which a compound or mixture of compounds is transferred from one phase into another. We will be looking specifically at an organic solvent extraction which is a type of solid-liquid extraction. This type of extraction utilizes an organic solvent that has a high affinity for the compound of interest. Most reactions produce a crude mixture of undesired reagent, byproducts, as well as the desired product. Extraction allows for the separation of a compound from a complex mixture. The different components can be eliminated by their different solubilities. Ultimately, through a simple distillation and filtration process, crystals of the desired product can be achieved.
Table of Reagent: Structure Mw. m.p. b.p. d.(density)
Nutmeg
Methylene Chloride 84.9328 -96.7 39.8 1.3255
Acetone 58.0798 -94.3 56.2 0.7857
Trimyristin
C45H86O6 723.1708 56 58 311
Specific Safety Precautions for Extraction:
1. Prolonged exposure to high concentrations of methylene chloride is harmful. This solvent should be used only in well-ventilated areas. Care should be taken to avoid inhaling the vapors of methylene chloride, and to avoid contact with skin. Gloves should be worn while handling this substance.
2. Methylene chloride should be disposed of in the waste halogenated solvents bottle.
3. Acetone should be discarded in the waste solvents bottle in the hood.
Precedure Data and Observation
1.
Place 5.001 g of ground nutmeg and 50 mL of methylene chloride in a 100 mL round bottom flask.
2.
Attach a water-cooled condenser to the flask and reflux the brown mixture for 30 minutes.
3.
Remove the heat. Allow the flask to cool for a short time.
4.
Filter the warm solution through a fluted filter paper into a 250 mL round bottom flask.
Rinse the solid residue on the filter paper with 5 mL of
Introduction:
Extraction is the physical process by which a compound or mixture of compounds is transferred from one phase into another. We will be looking specifically at an organic solvent extraction which is a type of solid-liquid extraction. This type of extraction utilizes an organic solvent that has a high affinity for the compound of interest. Most reactions produce a crude mixture of undesired reagent, byproducts, as well as the desired product. Extraction allows for the separation of a compound from a complex mixture. The different components can be eliminated by their different solubilities. Ultimately, through a simple distillation and filtration process, crystals of the desired product can be achieved.
Table of Reagent: Structure Mw. m.p. b.p. d.(density)
Nutmeg
Methylene Chloride 84.9328 -96.7 39.8 1.3255
Acetone 58.0798 -94.3 56.2 0.7857
Trimyristin
C45H86O6 723.1708 56 58 311
Specific Safety Precautions for Extraction:
1. Prolonged exposure to high concentrations of methylene chloride is harmful. This solvent should be used only in well-ventilated areas. Care should be taken to avoid inhaling the vapors of methylene chloride, and to avoid contact with skin. Gloves should be worn while handling this substance.
2. Methylene chloride should be disposed of in the waste halogenated solvents bottle.
3. Acetone should be discarded in the waste solvents bottle in the hood.
Precedure Data and Observation
1.
Place 5.001 g of ground nutmeg and 50 mL of methylene chloride in a 100 mL round bottom flask.
2.
Attach a water-cooled condenser to the flask and reflux the brown mixture for 30 minutes.
3.
Remove the heat. Allow the flask to cool for a short time.
4.
Filter the warm solution through a fluted filter paper into a 250 mL round bottom flask.
Rinse the solid residue on the filter paper with 5 mL of