Metabolic Syndrome Research Paper

Metabolic Syndrome: A Precursor of Heart Disease
In 1988, Dr. Gerald Reaven was awarded the Banting Medal for Scientific Research by the American Diabetes Association and introduced the term Syndrome X to the medical community. According to Dr. Reaven, “Syndrome X is a simple way to refer to a cluster of changes that encourage the onset and development of heart disease.” (Reaven, 2000, pg. 40) The medical terms Syndrome X, Insulin Resistance (IR), or Metabolic Syndrome (MetS) have been used interchangeably in resent research and MetS will be used in further discussion. The acquired risked factors that are included in the diagnoses of MetS will be discussed, as well as how they directly lead to heart disease. Cardiovascular disease is the medical
The purpose of the workshop was to come to a consensus on the definition of MetS for the clinical diagnosis and research purposes (Alberti, Zimmet, & Shaw, 2006, p. 469). The pathogenesis of MetS was also discussed. The group’s pathogenic summary is much like that of Dr. Reaver: genetics, as well as a poor weight management, will lead the risk factors to develop (p.86). Insulin resistance and central abdominal adipose fat tissue are the most prominent components of clinical
The body is overwhelmed with glucose and is forced to use it as the main source of energy instead of the body’s available fat. The fat has to go somewhere so it gets stored inside muscle cells, it remains in the blood as triglycerides and it may be stored in the liver. This cause the complication of a non-alcoholic fatty liver. The waist size will grow with adipose tissue as a result of IR. (Brand-Miller et al., 2007, p. 27). The vicious cycle will continue. Hyperinsulinemia can occur in patients with normal fasting glucose levels so the tests Homeostasis Model Assessment (HOMA0 and the Quantitative Insulin Sensitivity Check Index (QUICKI) or the hyperinsulinemic clamp method are needed to be run in order to properly diagnose IR (Reilly & Rader, 2003, p.