Microscale Synthesis of Acetylsalicylic Acid
Synthesis of Aspirin
Ling Tecson Gamido, Mitchiko Mariel M. Mizukami
Abstract
Acetylsalicylic acid, or also known as aspirin is known to be a drug that relives people of pain and is commonly used even today. It is synthesized from salicylic acid and ethanoic anhydride, both of small quantities. Phosphoric acid was used as a catalyst in the synthesis to speed up the process. Esterification is involved and the final product is aspirin with the presence of acetic acid as the byproduct. In order to create the powder form of aspirin, the process of crystallization was conducted and was run through vacuum filtration. After running through the help of an electronic instrument, the result that was achieved in this experiment was met due to the presence of esters in the graph in Figure 5; with a peak of 1297.89 at 1300-1100. There is also a match of 35.48 with ethyl salicylate. The objective, which is to create aspirin, has been completed due to the results shown by the data provided by an electronic instrument.A recommendation would be a more exact amount of reactants to be used. In this experiment, there was an excess of water and more acetic anhydride was used due to the salicylic acid not being able to dissolve at the amount of 0.3mL. Overall, this was a successful experiment where aspirin was synthesized properly. The melting point, using the meltemp, was at 146º-158 º.
Introduction
Aspirin is among the most fascinating and a versatile drug known to medicine and it is among the oldest. The first known use of an aspirin-like preparation can be traced to ancient Greece and Rome. Salicigen, an extract of willow and poplar bark, has been used as a pain reliever (analgesic) for centuries. In the middle of the last century it was found that salicigen is a glycoside formed from a molecule of salicylic acid and a sugar molecule. Acetylsalicylic acid (Aspirin) has been used as a drug that would lessen small pains within the body. It is considered as a salicylate
Ling Tecson Gamido, Mitchiko Mariel M. Mizukami
Abstract
Acetylsalicylic acid, or also known as aspirin is known to be a drug that relives people of pain and is commonly used even today. It is synthesized from salicylic acid and ethanoic anhydride, both of small quantities. Phosphoric acid was used as a catalyst in the synthesis to speed up the process. Esterification is involved and the final product is aspirin with the presence of acetic acid as the byproduct. In order to create the powder form of aspirin, the process of crystallization was conducted and was run through vacuum filtration. After running through the help of an electronic instrument, the result that was achieved in this experiment was met due to the presence of esters in the graph in Figure 5; with a peak of 1297.89 at 1300-1100. There is also a match of 35.48 with ethyl salicylate. The objective, which is to create aspirin, has been completed due to the results shown by the data provided by an electronic instrument.A recommendation would be a more exact amount of reactants to be used. In this experiment, there was an excess of water and more acetic anhydride was used due to the salicylic acid not being able to dissolve at the amount of 0.3mL. Overall, this was a successful experiment where aspirin was synthesized properly. The melting point, using the meltemp, was at 146º-158 º.
Introduction
Aspirin is among the most fascinating and a versatile drug known to medicine and it is among the oldest. The first known use of an aspirin-like preparation can be traced to ancient Greece and Rome. Salicigen, an extract of willow and poplar bark, has been used as a pain reliever (analgesic) for centuries. In the middle of the last century it was found that salicigen is a glycoside formed from a molecule of salicylic acid and a sugar molecule. Acetylsalicylic acid (Aspirin) has been used as a drug that would lessen small pains within the body. It is considered as a salicylate
References: Microscale synthesis of acetylsalicylic acid.(n.d.) Retrieved from http://www.docstoc.com/docs/23857240/Microscale-Synthesis-of-Acetylsalicylic-Acid(1) University of Colorado.(n.d.) Retrieved from http://orgchem.colorado.edu/hndbksupport/specttutor/irchart.html Moor Park College.(n.d.). Retrieved from http://sunny.moorparkcollege.edu/~chemistry/chemistry_1B_labs/experiment_fifteen.pdf Gettysburg College.(n.d.) Retrieved from http://www.gannon.edu/resource/dept/sim/new/chemexp_files/Most_used_ChemLabs/PDF_Files/Analysis_of_Aspirin.pdf