Crooks, the stable buck who works with the ranch horses, resides in a little shed connected to the barn by himself because he is the only black man on the ranch. He is named after his crooked back. Similar to Crooks, Candy the swamper is hunched back and lame. He had also lost one of his hands at the ranch.
The boss' son Curly, is also injured in a physical form. His hand got crushed , this injury reflects on his damaged masculatinity in general (the fight that had occured between him and Lennie). As for his wife, she is not physically impaired, but mentally. She acted how she did because of her isolation and loneliness from her marriage with Curly. She has regrets from marrying him due to her not having the chance to fullfil her dream to be an actor.
George is not only physically impaired, but also mentally aswell. physically he is really short, butmentally he doesnt really have the strength to properly leave Lennie behind. As for Lennie, bodily is he is the most able man in the novel, but mentally, he is incompatible with social life. This is what lead him, the puppy and Curley's wife to their death.