Ofloxacin Induced Toxic Epidermal Necrolysis Case Report
Ofloxacin induced Toxic epidermal necrolysis- A case report.
Introduction:
Toxic epidermal necrolysis, also known as Lyell's syndrome as it was described by Alan Lyell in 1956 who was a Scottish dermatologist. (1) Even though it is a rare but also a serious type of cutaneous adverse drug reaction. It is often characterized by widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes. That results in exfoliation of Epidermis which leaves an exposed and inflamed dermis and therefore there is increased susceptibility to infection leading to death. Consequently, there is a high mortality rate of 25-35 % and considerable long-term morbidity with Toxic epidermal necrolysis. (2) Although there are other etiologies also there, drugs are assumed or identified as the main …show more content…
Attention should be paid to possible cross-reactivity of certain drug groups. Data have been reported regarding genetic predisposition to drug hypersensitivity reactions, which are strongly associated with the major histocompatibility complex. (11) The pathogenesis of SJS/TEN is not fully understood. But it is believed to be immune-mediated, furthermore, keratinocyte apoptosis followed by necrosis is the pathogenic basis of the widespread epidermal detachment observed in SJS/TEN.
There are chances of death due to TEN which can be predicted by TEN-specific severity-of-illness score.(12) In the above-mentioned case, the patient had a score of 5, which indicated 90% mortality risk due to TEN. Here patient developed Toxic Epidermal Necrolysis after taking the tablet Ofloxacin. Due to severe desquamation of skin and hypovolemia patient died on the nineteenth day of reaction. His poor baseline conditions and uremic encephalopathy due to renal failure are also contributory factors for
Introduction:
Toxic epidermal necrolysis, also known as Lyell's syndrome as it was described by Alan Lyell in 1956 who was a Scottish dermatologist. (1) Even though it is a rare but also a serious type of cutaneous adverse drug reaction. It is often characterized by widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes. That results in exfoliation of Epidermis which leaves an exposed and inflamed dermis and therefore there is increased susceptibility to infection leading to death. Consequently, there is a high mortality rate of 25-35 % and considerable long-term morbidity with Toxic epidermal necrolysis. (2) Although there are other etiologies also there, drugs are assumed or identified as the main …show more content…
Attention should be paid to possible cross-reactivity of certain drug groups. Data have been reported regarding genetic predisposition to drug hypersensitivity reactions, which are strongly associated with the major histocompatibility complex. (11) The pathogenesis of SJS/TEN is not fully understood. But it is believed to be immune-mediated, furthermore, keratinocyte apoptosis followed by necrosis is the pathogenic basis of the widespread epidermal detachment observed in SJS/TEN.
There are chances of death due to TEN which can be predicted by TEN-specific severity-of-illness score.(12) In the above-mentioned case, the patient had a score of 5, which indicated 90% mortality risk due to TEN. Here patient developed Toxic Epidermal Necrolysis after taking the tablet Ofloxacin. Due to severe desquamation of skin and hypovolemia patient died on the nineteenth day of reaction. His poor baseline conditions and uremic encephalopathy due to renal failure are also contributory factors for