Orphenadrine Research Paper

According to Sweetman (2002), orphenadrine is a tertiary amine antimuscarinic (anticholinergic) with actions and uses similar to those of benzhexol. It also has weak antihistaminic and local anaesthetic properties. Antimuscarinic drugs are defined by, A Dictionary of Nursing (2008) as those inhibiting the action of acetylcholine, a neurotransmitter in the parasympathetic nervous system. These drugs relax smooth muscle, decrease the secretion of saliva, sweat and digestive juice, and dilate the pupil of the eye. As mentioned already orphenadrine is used as the hydrochloride in the symptomatic treatment of parkinsonism.

Katzung, et al. (2009) describe parkinsonism as
“Parkinsonism is characterized by a combination of rigidity, bradykinesia,