PCP/Angel Dust (Phencyclidine)
PCP/Angel Dust (Phencyclidine)
Classification: hallucinogenic
MW: 243.394 g/mol pKa: 8.29
Chemical Formula: C_17 H_25 N
IUPAC name:
1-(1-phenylcyclohexyl)piperidine
Description
Phencyclidine also known as PCP, is a hallucinogenic which is normally used as an veterinary anesthetic. PCP is similar to another hallucinogenic drug, Ketamine, based on their structure and effects on the person. PCP causes a dissociative state by inhibiting NMDA receptors (N-methyl-D-aspartate). [1,2,3]PCP is widely abused and is seen often on the streets. The drug has various ways to be administered where it can be smoked, administered intravenously, snorted, or taken orally. When taken heavily, it can become tolerated by the person, putting them in a dangerous state, where if they wanted to withdrawal many aftereffects would arise. When the drug was first created, it was solely used as an anesthetic, but after many extreme side-effects arisen, the drug was discontinued for many safety reasons. [2,3]
Mechanism of Action
PCP is a NMDA receptor antagonist with a pretty complex mechanism of action but studies shows that it blocks the receptors proceedings, by inhibiting the uptake of dopamine, 5-HT,and norepinephrine.[1,3,4] By this …show more content…
PCP has the ability to be extensively metabolized by a variety of metabolic routes in the body. The volume of distribution is roughly around 6.2 L/kg and a total clearance of 22.8 L/hr in the urine. [1,3,4]Phencyclidine has a wide range of a half-life due to the unindicated amount of administrative and the large amount that is usually adsorbed. The half-life that has been indicated in studies is around 7-26 hrs with usually an average of 21hrs. The principal mode of metabolism in a human’s body is by hydroxylation, giving two metabolites that are excreted in the urine.
Classification: hallucinogenic
MW: 243.394 g/mol pKa: 8.29
Chemical Formula: C_17 H_25 N
IUPAC name:
1-(1-phenylcyclohexyl)piperidine
Description
Phencyclidine also known as PCP, is a hallucinogenic which is normally used as an veterinary anesthetic. PCP is similar to another hallucinogenic drug, Ketamine, based on their structure and effects on the person. PCP causes a dissociative state by inhibiting NMDA receptors (N-methyl-D-aspartate). [1,2,3]PCP is widely abused and is seen often on the streets. The drug has various ways to be administered where it can be smoked, administered intravenously, snorted, or taken orally. When taken heavily, it can become tolerated by the person, putting them in a dangerous state, where if they wanted to withdrawal many aftereffects would arise. When the drug was first created, it was solely used as an anesthetic, but after many extreme side-effects arisen, the drug was discontinued for many safety reasons. [2,3]
Mechanism of Action
PCP is a NMDA receptor antagonist with a pretty complex mechanism of action but studies shows that it blocks the receptors proceedings, by inhibiting the uptake of dopamine, 5-HT,and norepinephrine.[1,3,4] By this …show more content…
PCP has the ability to be extensively metabolized by a variety of metabolic routes in the body. The volume of distribution is roughly around 6.2 L/kg and a total clearance of 22.8 L/hr in the urine. [1,3,4]Phencyclidine has a wide range of a half-life due to the unindicated amount of administrative and the large amount that is usually adsorbed. The half-life that has been indicated in studies is around 7-26 hrs with usually an average of 21hrs. The principal mode of metabolism in a human’s body is by hydroxylation, giving two metabolites that are excreted in the urine.