Parkinson's Disease Research Paper

Parkinson's Disease has been around since ancient times and man have been aware of the disease since then. In western Medicine a physician named Galen described Parkinson's as “shaking palsy” in AD. 175. A thorough medical essay was published about the “shaking palsy” in 1871 by London doctor James Parkinson. The disease was named after Parkinson and his essay was called “An Essay of the Shaking Palsy.” The essay paved the way for parkinson's and established it as medical condition.
Parkinson's disease is a progressive disorder of the nervous system and it affects several regions of the brain. An area of the brain that is affected heavily by Parkinson's is the substantia nigra. The substantia nigra is the part of the brain that produces dopamine
There is more than one gene that factors to the disease. Alpha synuclein is mutated a gene that affects a small number of parkinson's cases and it is located on chromosome 4. Alpha synuclein is the main element of Lewy bodies which are found in the cells of every patient with Parkinson's. When it comes to inheritance patterns there are a few but most people with parkinson's have no family history of the disease, these cases are often times sporadic or their pattern is unknown. In familial cases the gene that is altered determines the pattern. The genes that are involved are LRRK2 and SNCA in autosomal dominant patterns, this means that in most cases that the person affected has one parent with the same condition in this case Parkinson’s. The genes that are involved in an autosomal recessive pattern are PARK2, PARK7 and PINK1, this means that in most cases the person with the disease has parents that each carry one copy of the gene but do not show any signs or symptoms of the disease. Parkinson's can be sex-linked but more commonly is
These symptoms commonly include trembling and tremors that occur while one's body is not active, tremors usually occur in early stages on one side of the body and especially in the person's’ hand. Tremors commonly occur in the limbs such feet and arms. A person with Parkinson's also has movements which are slow and delayed, simple movements like smiling or blinking can become difficult and even simple task become harder to complete, this is called bradykinesia. Balance and coordination becomes unstable, Parkinson's weakens the body and mind over the course of the patient's life. People with parkinson's have a higher risk of getting dementia and have a high risk of becoming depressed. Lastly patients can lose their speech and their voices become softer and monotone and their words become slurred and hard to