Pelizaeus-Merzbacher

Pelizaeus-Merzbacher is an X-linked disease usually caused by mutations of the proteolipid protein 1 (PLP1) gene which leads to faulty myelination of the central nervous system (Chawla, 2014). It is a progressive and degenerative disease, which usually commences during the first few months of being born, however other milder cases can sometimes start during later on in childhood. There are two main forms of this disease: the most severe type called the connatal form, and the more common type which two thirds of patients have and shows typical symptoms of the disease, called the classical form (Yamamoto and Shimojima, 2013). The name was derived from two German physicians; Friedrich Pelizaeus first describing the disease in 1885, followed by