Preparation and Recrystallisation of Aspirin
Preparation and Recrystallisation of Aspirin
Contents Page
Synopsis iii
1 Introduction 1 1.1 Objective 1
1.2 Background 1
2 Theory 1
3 Procedure 2 3.1 Materials 2
3.2 Preparation 2
3.3 Recrystallisation 3
3.4 Determination of Melting Point 3
4 Results and Calculation 4 4.1 Mass 4 4.2 Percent yield 4 4.3 Melting Point 4 4.4 Appearance 4
5 Discussion 5
6 Conclusion 5
References R1
Synopsis
This report is based on preparation and recrystallization of aspirin. The objective of the experiment is to conduct the synthesis of aspirin and reinforce the skills of recrystallization and technique of melting point determination. Both experimental successes and errors were analyzed. The mass of recrystallized aspirin recorded was 0.85g, which led to a low percent yield of 27.1%. The melting point was 135.5 – 138.3 ˚C, but had a quite a wide range which could be due to impurities present. The aspirin had an appearance of a white, needle-like crystalline solid. If time permitted, the experiment could be repeated to improve the results, by reducing the errors which was analyzed. Overall, the experiment can be deemed as quite successful.
1 Introduction 1.1 Objective
The objective of this experiment is to learn to conduct the synthesis of aspirin, reinforce the skills of recrystallization and determination of melting point. 1.2 Background
The active ingredient in aspirin, acetylsalicylic acid, is a synthetic derivative of a compound, salicin found commonly in willow trees. Ancient Greeks had noted the medicinal effect of willow tree extracts, yet its active ingredient salicylic acid was only isolated until the 1800s. However, it was strongly acidic making it hard to swallow and caused irritation to the lining of the mouth and stomach. Only later in 1897, the process to synthesize an ester of salicylic acid,
Contents Page
Synopsis iii
1 Introduction 1 1.1 Objective 1
1.2 Background 1
2 Theory 1
3 Procedure 2 3.1 Materials 2
3.2 Preparation 2
3.3 Recrystallisation 3
3.4 Determination of Melting Point 3
4 Results and Calculation 4 4.1 Mass 4 4.2 Percent yield 4 4.3 Melting Point 4 4.4 Appearance 4
5 Discussion 5
6 Conclusion 5
References R1
Synopsis
This report is based on preparation and recrystallization of aspirin. The objective of the experiment is to conduct the synthesis of aspirin and reinforce the skills of recrystallization and technique of melting point determination. Both experimental successes and errors were analyzed. The mass of recrystallized aspirin recorded was 0.85g, which led to a low percent yield of 27.1%. The melting point was 135.5 – 138.3 ˚C, but had a quite a wide range which could be due to impurities present. The aspirin had an appearance of a white, needle-like crystalline solid. If time permitted, the experiment could be repeated to improve the results, by reducing the errors which was analyzed. Overall, the experiment can be deemed as quite successful.
1 Introduction 1.1 Objective
The objective of this experiment is to learn to conduct the synthesis of aspirin, reinforce the skills of recrystallization and determination of melting point. 1.2 Background
The active ingredient in aspirin, acetylsalicylic acid, is a synthetic derivative of a compound, salicin found commonly in willow trees. Ancient Greeks had noted the medicinal effect of willow tree extracts, yet its active ingredient salicylic acid was only isolated until the 1800s. However, it was strongly acidic making it hard to swallow and caused irritation to the lining of the mouth and stomach. Only later in 1897, the process to synthesize an ester of salicylic acid,
References: Singapore Polytechnic Inorganic and Organic Chemistry CP4006/CP8102 Lab Manual, 2012. Preparation and Recrystallization of Aspirin. Aspirin, 2009 [Online]. Available from: http://www.drugs.com/aspirin.html [Accessed 24 August 2009]. Aspirin, The Wonder Medicine, 2007 [Online]. Royal Society of Chemistry, UK. Available from: http://www.rsc.org/images/RSCaspirin_tcm18-159223.pdf [Accessed 2007]. gr33nbamb00, 2008. The Synthesis of Aspirin [Online]. Available from: http://vinstan.wikispaces.com/The+Synthesis+of+Aspirin [Accessed 30 December 2008]. Nick Henderson. 100 years of Aspirin [Online]. Aspirin Foundation, UK. Available from: http://www.aspirin-foundation.com/what/100.html