Rottlerin Synthesis
Rottlerin is an effective CaM kinase III inhibitor. Rottlerin inhibits protein kinases with some specificity for PKC [1].
CaM III is a major intracellular calcium receptor in eukaryotic cells that have been implicated in regulating diverse intracellular processes, such as cellular proliferation, cyclic nucleotide and cellular morphology and motility [2]. Protein kinase C, is a family of protein kinase enzymes that are involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory among many other functions. [3].
Rottlerin inhibited the activity of PKC isoenzymes, with IC50 values for PKCδ of 3-6 μM, PKCα, β, γ of
CaM III is a major intracellular calcium receptor in eukaryotic cells that have been implicated in regulating diverse intracellular processes, such as cellular proliferation, cyclic nucleotide and cellular morphology and motility [2]. Protein kinase C, is a family of protein kinase enzymes that are involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory among many other functions. [3].
Rottlerin inhibited the activity of PKC isoenzymes, with IC50 values for PKCδ of 3-6 μM, PKCα, β, γ of