Sickle Cell Anaemia Research Paper
All families with a history of the autosomal recessive disease Sickle cell anaemia should have all embryos screened with Pre-Implantation Genetic Diagnosis technology (PGD). If tested positive, treatment should be made compulsory for the child at a young age and will be treated with stem cell gene therapy. This disease has no personal relevance to me, however, there is currently 90K people suffering from Sickle cell anaemia in the United States. Sickle cell anaemia is relevant to society because it greatly reduces the quality of life of its sufferers and their families. Sickle Cell currently affects 1-500 African Americans and 1-1200 Hispanic Americans. Therefore, it should be made a priority to find a sustainable cure and make treatment widely
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23 chromosomes from the mother and 23 from father; each cell in the human body (Except gametes) contains 46 chromosomes arranged into 23 x and 23 y, which determine the sex of a person. On the 23rd pair of chromosomes, Males have an XY and females have an XX. Sickle cell anaemia is an autosomal recessive disease, which is inherited when both parents carry the “sickle cell trait”. Sickle cell anaemia is caused by a mutation in the protein subunit beta-globin of the Haemoglobin protein. The mutation causes abnormal versions of the beta-globin subunit which causes it to be produced in extremely low …show more content…
Dr Kohn introduced as anti-sickling gene into the hematopoietic stem cell to capitalise on the self-renewing potential of bone marrow stem cells. This effectively creates a continual source of healthy red blood cells that don’t sickle. The process involves medication to destroy the sickle cell sufferer’s bone marrow cells. The donor bone marrow is then injected into the patients’ blood stream. The transplanted stem cells will travel through the central venous catheter where they will begin to produce new cells after three weeks. Bone marrow is a soft fatty tissue found inside the centre of the bones where blood cells are made. Bone marrow/ stem cell transplants are very risky and often have negative side effects. An independent study conducted by the US National Marrow Donor Program predicted that the survival rate of an allogeneic bone marrow transplant was just above 62%
23 chromosomes from the mother and 23 from father; each cell in the human body (Except gametes) contains 46 chromosomes arranged into 23 x and 23 y, which determine the sex of a person. On the 23rd pair of chromosomes, Males have an XY and females have an XX. Sickle cell anaemia is an autosomal recessive disease, which is inherited when both parents carry the “sickle cell trait”. Sickle cell anaemia is caused by a mutation in the protein subunit beta-globin of the Haemoglobin protein. The mutation causes abnormal versions of the beta-globin subunit which causes it to be produced in extremely low …show more content…
Dr Kohn introduced as anti-sickling gene into the hematopoietic stem cell to capitalise on the self-renewing potential of bone marrow stem cells. This effectively creates a continual source of healthy red blood cells that don’t sickle. The process involves medication to destroy the sickle cell sufferer’s bone marrow cells. The donor bone marrow is then injected into the patients’ blood stream. The transplanted stem cells will travel through the central venous catheter where they will begin to produce new cells after three weeks. Bone marrow is a soft fatty tissue found inside the centre of the bones where blood cells are made. Bone marrow/ stem cell transplants are very risky and often have negative side effects. An independent study conducted by the US National Marrow Donor Program predicted that the survival rate of an allogeneic bone marrow transplant was just above 62%