Staphylococcus Pyogenes Research Paper
Streptococcus pyogenes
Research paper
MCB 2010C
March 17, 2014
Nature of Causative Organism
Streptococcus pyogenes, a group A streptococci, is a gram-positive, non-spore forming bacteria that can be seen as oval cocci chain forming shapes less than 2 micrometers in diameter under the microscope. It is a facultative anaerobe that can use fermentation for its metabolism. It needs a blood containing medium to grow and exhibits beta-hemolysis. It is a non-motile, nonspore forming bacterium. S. pyogenes has a number of virulence factors that work in its favor including a hyaluronic acid capsule. Hyaluronic acid is the ground substance in connective tissue so having a capsule made of this tissue cement gives it a good disguise that helps prevent …show more content…
Streptococcus pyogenes is host specific to humans. A group of scientists at the College of Veterinary Medicine at Cornell University tracked the evolution of S. pyongenes by looking at sister species from the pyogenic group.
They were able to identify through reconciliation analysis 113 genes that were gained on the lineage leading to S. pyogenes and almost half (46%) of these gained genes were phage associated and 14 showed significant matches to experimentally verified bacteria virulence factors. Subsequent to the origin of S. pyogenes, over half of the phage associated genes were involved in 90 different lateral gene transfer events, mostly involving different strains of S. pyogenes, but with a high proportion involving the horse specific pathogen S. equi subsp. equi, with the directionality almost exclusively (86%) in the S. pyogenes to S. equi direction (Lefebure, 2012).
Lefebure and his associates concluded that S. pyogenes adapted to a human host primarily through virulence factors and by building new regulation networks. By studying the
history of S. pyogenes genomic features, they hope to be able to develop better medical strategies for dealing with infection by this bacterium.
Current Clinical
Research paper
MCB 2010C
March 17, 2014
Nature of Causative Organism
Streptococcus pyogenes, a group A streptococci, is a gram-positive, non-spore forming bacteria that can be seen as oval cocci chain forming shapes less than 2 micrometers in diameter under the microscope. It is a facultative anaerobe that can use fermentation for its metabolism. It needs a blood containing medium to grow and exhibits beta-hemolysis. It is a non-motile, nonspore forming bacterium. S. pyogenes has a number of virulence factors that work in its favor including a hyaluronic acid capsule. Hyaluronic acid is the ground substance in connective tissue so having a capsule made of this tissue cement gives it a good disguise that helps prevent …show more content…
Streptococcus pyogenes is host specific to humans. A group of scientists at the College of Veterinary Medicine at Cornell University tracked the evolution of S. pyongenes by looking at sister species from the pyogenic group.
They were able to identify through reconciliation analysis 113 genes that were gained on the lineage leading to S. pyogenes and almost half (46%) of these gained genes were phage associated and 14 showed significant matches to experimentally verified bacteria virulence factors. Subsequent to the origin of S. pyogenes, over half of the phage associated genes were involved in 90 different lateral gene transfer events, mostly involving different strains of S. pyogenes, but with a high proportion involving the horse specific pathogen S. equi subsp. equi, with the directionality almost exclusively (86%) in the S. pyogenes to S. equi direction (Lefebure, 2012).
Lefebure and his associates concluded that S. pyogenes adapted to a human host primarily through virulence factors and by building new regulation networks. By studying the
history of S. pyogenes genomic features, they hope to be able to develop better medical strategies for dealing with infection by this bacterium.
Current Clinical