Substitution Reactions Lab Report
Substitution Reactions of 3-phenyl-1-phenol, 2-pentanol, and 2,4-dimethyl-3-pentanol
Samantha Sparks, Isi Nosegbe and Sabrina Becker.
Department of Chemistry, IUPUI, 402 N. Blackford St., Indianapolis, IN 46202
This project was collaborated on by three different organic chemistry students, who individually synthesized and researched each of the three substitution reactions in this experiment.. The first reaction was an Sn2 reaction of 3-phenyl-1-propanol with NaBr and H2SO4 to create1-bromo-3-phenylpropane. Though multiple trials were ran no successful results of reaction one were obtained. Reaction two was a Sn2 of 2-pentanol with H2SO4 and NaBr. Changes were made to each run of the reaction, but the organic product obtained showed minimal …show more content…
Having a solid knowledge of these is key to being productive in the lab, and obtaining good results when running experiments. The reason this information is available in the first place is due to countless hours of laboratory work by chemistry pioneers. From their efforts and organized results, we now know that there are some expected pathways that reactants will follow in combination with other chemicals, in the right conditions. Substitution is one such pathway, in which a molecule with a sigma bonded group has it removed, and replaced with a different one. It is simply the exchange of functional groups that are bonded the same way to the R group, hence the name ‘substitution’. There are two kinds of substitution that this project focused on: SN1, and SN2. The former is a reaction that is 1st order, and the latter 2nd order. The letters in the abbreviations represent the substitution and the nucleophile (which attacks the carbon hosting the alcohol) to get the entire reaction …show more content…
SN2 reactions occur in one fell swoop, thanks to a transition state. For this assignment, three compounds with alcohol functional groups were reacted with halides of hydrogen, and the conditions were varied under a controlled environment to see if the products would be consistent with the known pathways for mechanisms of SN1 and SN2 reactions, with the alcohol functional group leaving, and the halogen taking its place in a seamless exchange. The position of the alcohol on the starting material was also a factor taken into account with each reaction. The reactions are detailed
Samantha Sparks, Isi Nosegbe and Sabrina Becker.
Department of Chemistry, IUPUI, 402 N. Blackford St., Indianapolis, IN 46202
This project was collaborated on by three different organic chemistry students, who individually synthesized and researched each of the three substitution reactions in this experiment.. The first reaction was an Sn2 reaction of 3-phenyl-1-propanol with NaBr and H2SO4 to create1-bromo-3-phenylpropane. Though multiple trials were ran no successful results of reaction one were obtained. Reaction two was a Sn2 of 2-pentanol with H2SO4 and NaBr. Changes were made to each run of the reaction, but the organic product obtained showed minimal …show more content…
Having a solid knowledge of these is key to being productive in the lab, and obtaining good results when running experiments. The reason this information is available in the first place is due to countless hours of laboratory work by chemistry pioneers. From their efforts and organized results, we now know that there are some expected pathways that reactants will follow in combination with other chemicals, in the right conditions. Substitution is one such pathway, in which a molecule with a sigma bonded group has it removed, and replaced with a different one. It is simply the exchange of functional groups that are bonded the same way to the R group, hence the name ‘substitution’. There are two kinds of substitution that this project focused on: SN1, and SN2. The former is a reaction that is 1st order, and the latter 2nd order. The letters in the abbreviations represent the substitution and the nucleophile (which attacks the carbon hosting the alcohol) to get the entire reaction …show more content…
SN2 reactions occur in one fell swoop, thanks to a transition state. For this assignment, three compounds with alcohol functional groups were reacted with halides of hydrogen, and the conditions were varied under a controlled environment to see if the products would be consistent with the known pathways for mechanisms of SN1 and SN2 reactions, with the alcohol functional group leaving, and the halogen taking its place in a seamless exchange. The position of the alcohol on the starting material was also a factor taken into account with each reaction. The reactions are detailed