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Summary Of The Novel Isocyanide-Based Mcrs

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Summary Of The Novel Isocyanide-Based Mcrs
In 1998, novel isocyanide-based MCRs were de-scribed by Blackburn,14 Bienaymé,15 and Groeb-ke16 which involve the reaction between a 2-aminoazine, an aldehyde, and an isocyanide in the presence of a catalyst such as Sc(OTf)3,14 perchlo-ric acid15 or glacial acetic acid.16 These methods led to simple construction of imidazo[1,2-a]azines but required long reaction times and the work-ups were complicated. In addition, imidazo[1,2-a]azine syntheses have been carried out under microwave irradiation in the presence of montmorillonite K10,17 Sc(OTf)3,18 nonpolar solvent,19 and ionic liquid.20 Improved conditions have also been re-ported in recent
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