Synaptic Plasticity Essay

Our daily life is full of information and data. Mammalian brain has a unique ability called neuronal plasticity. Let us to experience and modify the neural circuitry and thereby to modify future thought, behavior, and feeling. Synaptic plasticity is one of the important neurochemical foundations of learning and memory. Hippocampus area and specially CA1 are the most interesting area to study synaptic plasticity. Cellular structure in this region is presented. These cell connect to each other and neighbor to encode various kind of memory encoding. Repetition of a task is the most critical factor for memory consolidation, which strength the cell connection and call Long term potentiation (LTP). LTP change neuronal connection to connect more sufficiently
, so called the cellular mechanism for learning and memory (Change some receptors and neurochemical substance inside the cell). LTP could also be modify during experimental study. Using in vitro stimulation method we will try to modulate two critical substances secreted in synaptic region during memory formation including; dopamine and BDNF. We aimed to better understand memory formation mechanism. Evaluate cellular stimulation effects of substance secretion and finally seek to explain dopamine and BDNF role in this regard. Once there be a clear understanding of this process, we may be able to apply the finding on some neurological disorder like Alzheimer disease.