John Green derives the book's title from a famous line in Shakespeare’s Julius Caesar: "The fault, dear Brutus, is not in our stars, but in ourselves, that we are underlings." There have been more than one interpretation of the Shakespearian quote. One interpretation and probably the one that is most know throughout the Shakespearian literature world is “fate is not what drives men to their decisions and actions, but rather the human condition.”
The title of the John Green book, The Fault in Our Stars is as multi-layered as the book itself. The title can be interpreted or the meaning that can be derived from the book can only be determined from the reader’s point of view. When he or she has finished the book the reader has to decide what interpretation he or she was able to understand from there ideals of the book. One of the interpretation that is was able to derive was that the fault is in the nature of things not in how you do them, or even just in yourself generally. Another interpretation that I also was able to derive from the text of the book was the fault is “in” our stars, and we can do nothing about it. We don't have a choice in the matter. There are multiple more meanings that is probably hidden within the title.
Since the book is multi-layered, the title if just as multi-layered. This is because of the book and all the hidden meanings and messages that are within the book. There are just too many interpretations that readers are able to determine from reading the book. That is why if anyone who reads this and disagrees with any of my interpretation, I would truly suggest reading the book and try to see what you determined or interpreted what the meaning of the title is.