Different approaches are employed to generate and also deliver a vaccine; each method has its own merits and demerits. Few of these merits are discussed below: The main advantage of genetically engineered organisms used as vaccines is that the proteins that are formed do not contain the complete viral strain. So it has no risks related to accidental immunization with live virus. Direct cloning into the DNA of vaccinia virus is promising, however vaccines using this method have not been released into the market yet (Nagy, 2001).
Recombinant form of vaccinia virus such as in genital herpes virus, a gene from its DNA can be multiplied and then can be inoculated into humans. Then the vaccinia virus can give a mild infection and further can express the protein for herpes virus to elicit immune response (Nagy, 2001). The basic principle that was used in production of today’s vaccines are based on the first vaccination by Edward Jenner for over 100 years ago where he introduced the world the concept of vaccination that led to the elimination of smallpox. The first therapeutic product Humulin, which was made commercially by genetically engineered bacterium. There is also genetically engineered malarial vaccine SPF – …show more content…
So the authorities should take all the factors into account when developing GMO’s vaccines (Funk and Rainie, 2015). These are factors are often neglected in few non-human viruses that are used as vaccines, where xenotransplantation is a good example where the environmental risk factors are often neglected. This transplantation employs the cells, tissues, and whole organs from animals due to shortage of human organs. Non-human primates and pigs are the main sources of cells and tissues (Funk and Rainie,