Verapamil Lab Report
Maria et al.determined that verapamil is freely soluble in ethanol and methanol i.e., (>100 mg/mL) , soluble in water( 83 mg/mL) and is practically insoluble in hexane (0.001 mg/mL)(Maria et al., 2010).
Sadhana et al. determined the solubility of drug in different pH ranges from pH 1.2 – pH 7.4. By adjusting the pH of deionised water by 1N Hcl or 1N NaOH various pH solutions were prepared.In 2ml of different pH solutions,excess quantity of drug was added and dissolved to obtain a saturated solution of drug.Solution was shaken intermittently in order to attain equilibrium with the undissolved particles and after 24hours this solution was diluted with 0.1N Hcl and analyzed by UV spectrophotometer at 278nm (Sadhana et al., 2013).
Results:
Sadhana et al. determined the solubility of drug in different pH ranges from pH 1.2 – pH 7.4. By adjusting the pH of deionised water by 1N Hcl or 1N NaOH various pH solutions were prepared.In 2ml of different pH solutions,excess quantity of drug was added and dissolved to obtain a saturated solution of drug.Solution was shaken intermittently in order to attain equilibrium with the undissolved particles and after 24hours this solution was diluted with 0.1N Hcl and analyzed by UV spectrophotometer at 278nm (Sadhana et al., 2013).
Results: