Sulfasalazine Lab Report
A Brief Introduction to Sulfasalazine
Sulfasalazine is a sulfa drug derived from mesalazine (5-aminosalicylic acid known as 5-ASA). Often prescribed as an effective medication against inflammation-related symptoms, it has multifaceted effects towards several diseases including intestinal diseases as well as rheumatoid arthritis.1 Sulfasalazine has been widely used for decades since its approval by FDA.2
Apart from the common uses, researchers also recently discovered that sulfasalazine could potentially fight against cancer stem cells by targeting a certain type of cell transporter. The effect of the drug molecule on the transporter may disrupt cellular functions and activities, therefore disallowing the cancer cells to escape cell apoptosis, …show more content…
The reaction process is shown by Figure 1 below. Equimolar amounts of sulfasalazine and cholinium hydroxide were mixed as a 45% solution in methanol. The sulfasalazine would ionise in the solution to form an ion, which would combine with the cholinium ion present in the solution to give the desired product. The methanol solvent was evaporated, and the remaining residue was dehydrated by vacuum. The product obtained appeared as a red glassy …show more content…
Moslemi et al. has proposed a method to synthesise a type of hydroxyapatite HMN transporter particles. 1.67M Ca(NO3)2`4H2O was dissolved in ethanol and added at a fixed rate into the 1M NH4H2PO4 solution at room temperature. A gel-like solution with white precipitate was obtained and left at room temperature for 24 hours. It was then filtered and washed several times by using double distilled water to get rid of the inorganic ions as impurities. The crude product was washed repeatedly using acetone, filtered and dried at 80 °C for 12 hours in the oven. The dried fine solid was calcined at 600 °C for 5 hours. The hydroxyapatite product was chemically modified by mixing with aminopropyl trimethoxysilane (figure 2) to enhance its abilities in biological system. The transportation ability of sulfasalazine by this drug carrier was also tested in their experiment, proving that such a modified structure would achieve a more efficient drug
Sulfasalazine is a sulfa drug derived from mesalazine (5-aminosalicylic acid known as 5-ASA). Often prescribed as an effective medication against inflammation-related symptoms, it has multifaceted effects towards several diseases including intestinal diseases as well as rheumatoid arthritis.1 Sulfasalazine has been widely used for decades since its approval by FDA.2
Apart from the common uses, researchers also recently discovered that sulfasalazine could potentially fight against cancer stem cells by targeting a certain type of cell transporter. The effect of the drug molecule on the transporter may disrupt cellular functions and activities, therefore disallowing the cancer cells to escape cell apoptosis, …show more content…
The reaction process is shown by Figure 1 below. Equimolar amounts of sulfasalazine and cholinium hydroxide were mixed as a 45% solution in methanol. The sulfasalazine would ionise in the solution to form an ion, which would combine with the cholinium ion present in the solution to give the desired product. The methanol solvent was evaporated, and the remaining residue was dehydrated by vacuum. The product obtained appeared as a red glassy …show more content…
Moslemi et al. has proposed a method to synthesise a type of hydroxyapatite HMN transporter particles. 1.67M Ca(NO3)2`4H2O was dissolved in ethanol and added at a fixed rate into the 1M NH4H2PO4 solution at room temperature. A gel-like solution with white precipitate was obtained and left at room temperature for 24 hours. It was then filtered and washed several times by using double distilled water to get rid of the inorganic ions as impurities. The crude product was washed repeatedly using acetone, filtered and dried at 80 °C for 12 hours in the oven. The dried fine solid was calcined at 600 °C for 5 hours. The hydroxyapatite product was chemically modified by mixing with aminopropyl trimethoxysilane (figure 2) to enhance its abilities in biological system. The transportation ability of sulfasalazine by this drug carrier was also tested in their experiment, proving that such a modified structure would achieve a more efficient drug