In looking at sickle-cell anemia, we are interested in studying the gene that codes for…
Sickle cells can clog vessels depriving tissues of oxygen. As spoken of in two articles (US News and World Report). Sickle cells have a shorter life span…
1. Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.…
Sickle cell anemia is the most common form of sickle cell disease which is an inherited, autosomal recessive disorder that causes an abnormal hemoglobin cell. The person with this specific disorder inherited hemoglobin S from both parents, also known as homozygous (Lewis, Dirksen, Heitkemper, & Bucher, 2014, pp. 644-647). This hemoglobin S results from the substitution of valine for glutamic acid on the B-globin chain of hemoglobin, and this ultimately causes the erythrocyte to stiffen and elongate taking a sickle shape in response to low oxygen levels (Lewis et al., 2014, pp. 644-647). Due to the sickle cells elongated shape, and its stiff and sticky consistency it tends to get stuck in capillaries and vessels, and blocks blood flow to limbs and organs (Lewis et al., 2014, pp. 644-647). The major problems with sickle cell anemia is due to their sickled shape, reduced life expectancy and their ability to carry enough hemoglobin or transport it properly to…
Sickle cell anemia is a disease where your body produces abnormally shaped red blood cells. The cells are shaped like a crescent or sickle used to cut wheat. As the sickle cell blood cells don't last as long as normal round red blood cells this then leads to anemia. The sickle cells can also get stuck in blood vessels, blocking blood flow and are unable to get oxygen around the body effectively.…
Sickle cell disease is an inherited disorder in which red blood cells are abnormally shaped. This abnormality can result in painful episodes, serious infections, chronic anaemia, and damage to body organs.…
Sickle Cell Anemia, also known as Sickle Cell Disease, is a disease that causes the production of abnormal hemoglobin. The red blood cells (RBCs) carry oxygen to organs and tissues. Hemoglobin, a molecule in the RBCs, is a protein that attaches to the oxygen in the lungs and carries it to all parts of the body. Hemoglobin takes on the oxygen, and releases carbon dioxide, a process known as oxygenation. In the tissues, deoxygenation occurs where the processes is reversed, when hemoglobin releases oxygen and takes on carbon dioxide. When the RBCs are healthy, they can easily move through the tiniest blood vessels throughout the body because of their flexibility. The hemoglobin S is fragile and abnormal in Sickle Cell Anemia, and the RBCs are pointy with a shape like the alphabet letter "C" or the crescent moon. This makes the RBCs difficult to move pass through the blood vessels. The RBCs become hard, and can get stuck in blood vessels, and often clog the spleen. This causes pain, infection, and poor blood flow in patients that have Sickle Cell Anemia. The RBCs also block blood flow to organs, such as the heart, lungs, brain, etc., which can lead to stroke, damage to organs, especially the spleen, acute chest syndrome, disability, and sometimes, even death.…
INTRODUCTION: “Pain” sudden or chronic, lasting from a few hours to a few days; from a few weeks to a few months evolving from an adhesive substance in red blood cells. The “Pain” is inherited by an retriction blood flow through the body do to an abnormality in the cells. “Sickle Cell Anemia” a chronic illness discovered in 1910 by an American physician named James Bryan Herrick. Sickle Cell is more that just pain; it is a disease that is affected by abnormal blood cells that has an adhesive formation causing the natural flow to be compromised. As a result, these abnormal cells become fixed in the blood stream and not flowing to major body organs causing extreme pain and even a stroke. Why is this process painful? Have sickle cell patient become tolerant to pain or is it because some of them handle self-care management? For many years there has been a link between Sickle Cell Anemia and Pain caused by the stickiness of the blood cells. When this occurs, it decreases normal blood flow to the major organs causing strokes.(citation ). Sickle cell anemia is most common in people whose families come from Africa, South or Central America (especially Panama), Caribbean islands, Mediterranean countries (such as Turkey, Greece, and Italy), India, and Saudi Arabia. In the United States, it's estimated that sickle cell anemia affects 70,000–100,000 people, mainly African Americans. The disease occurs in about 1 out of every 500 African American births. Sickle cell anemia also affects Hispanic Americans. The disease occurs in more than 1 out of every 36,000 Hispanic American births (Citation).More than 2 million Americans have sickle cell trait. The condition occurs in about 1 in 12 African Americans. In people with sickle cell disease, approximately 50% do not survive beyond age 20 years, and most people do not live past 50 years of age (Citation)…
The articles by Thompson and Meier share the same information about sickle cell disease, the complications and risk of procedures, and what type of treatments are available. Although, the article by Thompson goes farther in depth on the cure of stem cell research and transplants versus the article by Meier with the main focus of symptoms and symptom…
Sickle cell is inherited and is normally only found in Black Americans. The blood cells are shaped differently and it due to a genetic defect. (WebMD, 2014) This causes the blood cells to eliminate themselves rather quickly causing lack of oxygen to the organs in the body. The reason this disease is so painful is because the blood cells become trapped in the blood vessels. (WebMD, 2014)…
the supply of oxygen gets cut off. A normal blood cell lives up to 120…
The first case of Sickle Cell Anemia was first published in 1910 by scientists, and has since then been followed by at least six decades of many observations, which include genetic, molecular, and pathologic observations (Wethers, 2000) Large bodies of clinical data has on the evolution of Sickle Cell Anemia from birth has been gathered on studies of children since the 1970's (Wethers, 2000) The United States has studied 3,500 patients…
In 1981, scientists discovered that TAC is caused by B19 infection in children with sickle-cell anaemia (Serjeant et al., 1981) .…
In the mid-1920s, Di Guglielmo in Naples described a group of marrow disorders associated with bizarrely shaped erythrocytes and low peripheral…
Anemia is a disorder of the blood. It occurs when your body does not produce enough erythrocytes or red blood cells (RBCs). Without the erythrocytes oxygen can not be adequately delivered to the tissues and organs throughout the body. This will cause you to become weak and tired. A person may also experience headaches, skin pallor, and faintness. Your body may attempt to compensate for these symptoms by speeding up the heart rate and respiratory rate. This is the body’s attempt to return oxygen levels to normal(Thibodeau and Patton, 2005).…