Act One
Serapion describes foreboding omens (of storms, whirlwinds, and the flooding of the Nile) of Egypt’s impending doom. Alexas, Cleopatra’s eunuch, dismisses Serapion’s claims and is more concerned with Cleopatra’s relationship with Antony. He sees that Cleopatra dotes on Antony and worries that Antony will not continue seeing Cleopatra. Thus, Serapion hosts a festival to celebrate Antony’s honor.
Ventidius, a Roman general, comes to aide Antony in Alexandria. Ventidius disagrees with Antony’s relationship with Cleopatra and offers to give Antony troops if he leaves her. Although Antony is insulted by Ventidius’s opinions regarding Cleopatra (and refuses to hear anything negative about her), Antony agrees.
Act Two
Cleopatra mourns about her situation without Antony. Charmion, Cleopatra’s lady in waiting, attempts to set up a meeting between Cleopatra and Antony, but she is unsuccessful. Cleopatra thus sends Alexas to try to win back Antony using gifts (jewels including a bracelet). Alexas suggests that Cleopatra should tie the bracelet onto Antony’s wrist. In the subsequent meeting between Cleopatra and Antony, Ventidius appears and tries to proclaim how Cleopatra is not Antony’s rightful partner and would betray him for her own safety. However, Cleopatra wins this argument by demonstrating a letter showing that she refused Egypt and Syria from Octavius. Antony is overjoyed by Cleopatra’s decision and proclaims his love for her.
Act Three
Antony is returning from battle and is overwhelmed with love for Cleopatra. Ventidius comes to speak with Antony, who attempts to flee unsuccessfully. Antony does not want to go back to war but doesn't know how to stop it. He believes Dolabella can help him and Ventidius brings Dolabella out. Dolabella, Antony’s friend, appears after Antony’s success in battle. Dolabella was banished for his love for Cleopatra, but he returns to a warm welcome from Antony. Dolabella offers a gift that will bring