synthesized by treating with malononitrile in the presence of piperidine as a base and ethanol as solvent. The detailed synthesis procedure given in the experimental section. The structure and purity of TPC was unambiguously confirmed by 1H and 13C NMR spectroscopy. The synthesized TPC is red in color and appeared non-fluorescent‚ the fluorescence of triphenylamine was completely switched-off in solid state. The UV-visible spectrum shows the strong absorbance at 460 nm and at 310 nm. In order to check
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it more likely that the low recovery was due to the solution ‘oiling out.’ This could be avoided in the future by maintaining the temperature of the solution below the melting point of the crystals. Post Lab Questions 4.Upon analysis of the 1H NMR spectrum of benzoin it was determined that the peak at 4.6PPM is the proton from the OH. The peak at 5.99PPM is the CH proton. II. Introduction The purpose of this lab was to produce benzoin using thiamine as a catalyst in order to get 2 mols
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Synthesis of Acetanilide Reaction O NH2 + H3C C O O C CH3 O N C CH3 H + H3C O C OH Aniline Acetic anhydride Acetanilide Acetic acid Purpose: Acetanilide is a useful precursor to many pharmaceuticals such as acetaminophen and penicillin. Experimental Procedure. (Estimated time: 1.5 h.) Unless otherwise noted‚ all manipulations should be done in the chemical fume hood. Place 100 µL of aniline into a tared 10 X 75-mm test tube (standing in a small beaker or Erlenmeyer flask). Now add
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Isolation of Product – All other amounts specified in this section should be followed without doubling. 4. Isolation of Product – Substitute 1.0 mL of cold 3.0 M HCl for 1.0 mL of cold 0.1 M HCl. 5. Purification and Characterization – Will not obtain an NMR spectrum. Reaction Scheme: Data and Results: Compound MW (g/mol) Amount Mmol Mp (degrees C) Bp (degrees C) 4-tert-butylcylcohexane 154.25 103 mg 0.67 47 – 50 Methanol 32.04 100 µL 65 Sodium Borohydride reducing solution 37.83 200
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Chris Holet 7 – 20-12 Steriochemistry of Bromine Addition to trans-Cinnamic Acid Purpose: To carry out the addition of bromine to trans-cinnamic acid and to identify the product from its melting point. Molecular Structures and Chemical Reaction(s): Results and Calculations: Table of reagents Name Density (g/ml) Amount used Amount # moles Bromine (excess) Trans-cinnamic Acid 1.246 g/cm3 0.148g – do conversion Dichloromethane 1‚3266 g/cm3 -
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vary widely in color‚ the diversity of this parallel synthesis becomes obvious. It includes techniques on diazotization and electrophilic substitiution. The experient belo is made to allow studens to btain pure compounds that can be characterized by NMR and other analytical techniques‚ but color test is well enough for synthesizing the dyes and purification process is omitted. Safety considerations. Due diligence should be exercised in this reaction. The scale of the work is such as to minimize
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the flavors and aromas of certain plants. Most conjugated dienes can form Diels-Alder with maleic anhydride.Trienes such as β-Myrcene (C10H16) may also form such adducts if at least two of their double bonds are conjugated. The IR‚ melting point‚ and NMR should be able to identify the two bands which arise from the carbonyl stretching modes and also identify the diene found in eucalyptus oil. Procedure: • Dissolve 5.00g of eucalyptus oil in 10ml of anhydrous diethyl ether • Add calculated
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org/suppdata/py/b9/b9py00316a/b9py00316a.pdf (accessed august 2012) D. Condenser Franck Paté‚ Hélène Gérard‚ Hassan Oulyadi‚ Aurélien de la Lande‚ Anne Harrison-Marchand‚ Olivier Parisel Jacques Maddaluno. Shuffling Lithiated Mixed Aggregates: NMR and Car-Parrinello Molecular Dynamics Reveal an Unexpected Associative Pathway. The Royal Society of Chemistry [online] 2008 vol2 p1-4 http://www.rsc.org/suppdata/cc/b8/b814961e/b814961e.pdf (accessed august 2012) E. Volumetric flask Jain‚ Pritam
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Synthesis of 3-Acetylcoumarin Introduction In thi lab we were asked to make coumarin. Coumarin is a fragrent organic chemical compound. It is a natural substance found in many plants. The name comes from the french term for tonka bean. The substance was first isolated as a natural product in 1820. Coumarin has been showed to be useful in biological activity‚ but they have been approved for few pharmacutical uses. It has been reported that coumarin activity includes HIV‚ tumors
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Abstract: This experiment synthesized H-Gly-Phe-OH dipeptide using “Fmoc chemistry”. The first part of experiment was the synthesis of L-phenylalanine methyl ester hydrochloride. The methyl ester can be synthesised by reaction of thionyl chloride‚ SOCl2 and dry methanol with L-phenylalanine under reflux condition. The peptide bond was formed later in the experiment‚ where HBTU‚ DiPEA and a solution of Fmoc-Gly-OH in DMF were added to a solution of L-phenylalanine methyl ester hydrochloride in DMF
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