The activities of MDM2 are highly controlled by extracellular and intracellular stress signals.These signals include genotoxic stress signals‚ ribosomal stress‚ oncogenic activation‚ and psychological stress signals. They function through distinct signalling pathways to regulate the ability of MDM2 to bind with p53‚ MDM2 E3 ubiquitin ligase activity‚ and the cellular localization of MDM2. The ability of MDM2 to export p53 to cytoplasm is blocked by the phosphorylation of MDM2 at these two positions
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Management of Depository Institutions 3505 Fall 2014 Problems: 1. A bank is planning to make a loan of $5‚000‚000 with duration of 7.5 years to “Jumbo Manufacturing”‚ a young and aggressive firm. The loan rate is 12% and the servicing fee is 50 basis points. The bank estimates that with a probability of 95%‚ the risk premium on the loan will not increase by more than 4.2%. The average cost of funds for the bank is 10 percent. The bank manager wants to use the RAROC approach to make a decision
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Strategies for dealing with challenging behaviour: Given the position that Kerri is in I would suggest to her that she has counselling. This may be a challenge depending on how willing Kerri would like to open up and talk about her problems‚ it may be a struggle however if will be really beneficial for Kerri given her situation. I would like to delve into her lifestyle and she how much she values herself and what gives her the urges to consume alcohol and drugs. I would also like to try and build
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Unit 4; P5- Lesson plan Activity number: 3 Date planned: Setting: Age of children: 6-8 Number of adults: 1 Planned activity: Number bingo (table top activity) Structured/unstructured: Structured Immediate context: Classroom Type of supervision planned: Resources and equipment planned: Board game Counters Big foam dice Prizes (1st‚ 2nd‚ 3rd prize and packet of everyone for taking part) Preparation time: 5-10 minutes Activity time: 20-30 minutes Health‚ safety and hygiene
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Task 1 P3 My health education campaign is about eating 5 a day (fruit and vegetables) I want to promote this and get people from different social class to start eating healthy cheaper. Before doing my health campaign I had to find the appropriate approach that I was going to use‚ the target group and the resources that were available for me. When I was designing my health education campaign I made sure that I followed certain principles. I carried out a small scale health education campaign
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P5: Explain the legal and ethical issues in relation to the use of business information In this task I am going to explain about each of the legal issues and the ethical issues individually and explain how businesses use these. What is the Data Protection Act 1998? This Act came into force in 1998 and this aims to protect an individual’s right to privacy of their personal data of which is taken and handled by businesses. Personal data does not just mean personal information; it means any data
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Imagine you are starting a Web business and want to incorporate cloud technology. Describe how you would incorporate cloud technology into your business model. Justify your response. If I was starting a wed based business I would incorporate cloud technology in to my business by cost analyzes. Cloud computing saves money with Saas services since you are paying for what you need and use. It also takes away having to worry about the maintenance and upkeep of a server. It is cheaper to use cloud computing
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|P2 P3 M1| Principles of effective communication General Skills Cultural Differences: Cultural differences are present wherever you travel to‚ you will come across cultural differences‚ and these can vary quite a bit‚ such as the language people use e.g. English people say "Chips" compared to Americans who say "Fries”. A businessman may find himself in the middle of cultural differences quite often and thus‚ will have to devise methods as to how to make sure no one is offended or that he
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SFX TESCO COMPARISON DIRECTOR The director of SFX will be the principle‚ who serves as an educational director in charge of the college. Her job as the director includes over seeing that everything in the college runs smoothly‚ managing the policies and procedures to ensure that all the students who have enrolled to study at SFX are safe while they are within the environment and also receive they best education the college can offer. Tesco’s director ensures that the business is meeting its goals
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date Friday 9th May 2014 Assessor Mr Muhammad P6 describe how business markets are regulated in the UK (Case Study) M3 explain why the government needs to regulate business markets P7 explain how EU requirements influence business markets in the UK D2 evaluate the effectiveness of the regulatory regime in a selected market The main purpose of this assignment is to: describe how business markets are regulated in the UK and explain how EU requirements influence business markets in the UK. Scenario:
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