Chemistry 3373F Lab Manual 2008 Modified 11/07 Table of Contents Chem 3373 Laboratory Schedule for Fall 2008.............................................................................2 The Benzoin Condensation of Benzaldehyde ..............................................................................3 Synthesis of Dilantin and Related Compounds (two weeks).........................................................6 Synthesis of an Alkaloid: Pseudopelletierine (two weeks) .............
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Experiment: Preparation and Identification of Dibenzylidene Acetone Purpose: Prepare dibenzylidene acetone by the famous Claisen-Schmidt condensation reaction. Learn the experimental skills of organic synthesis‚ separation‚ purification‚ structural characterization by instrumental analysis. Train the ability to solve the practical problems. Principle: Aromatic aldehydes can have aldol reaction with aldehydes or ketones which have α-hydrogen atoms‚ dehydrate to form high yield of α‚β-unsaturated
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takes place. Actually this reaction is a combination of two reactions. One is ’Michael Addition ’ and the other is ’Aldol Condensation ’. Robinson Annulation Mechanism In the first step‚ Micheal addition takes place to an α‚β-unsaturated ketone. Enolate is formed and tautomerization takes place for further reaction. Cyclization takes place. That is‚ aldol condensation reaction to form six-membered cyclic product. Further hydrolysis results in the formation of α‚β-unsaturated cyclic ketones
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Aldol Condensation: Synthesis of Dibenzalacetone Aldol Condensation: Synthesis of Dibenzalacetone Leah Monroe May 15‚ 2003 Organic Chemistry Lab II Experiment performed on May 6 and 8‚ 2003 Abstract: The purpose of this experiment was to synthesize dibenzalacetone via an aldol condensation reaction between acetone and benzaldehyde. This was done by mixing the two reactants with NaOH and ethanol‚ then allowing the reaction to sit for thirty minutes. The crystals were then washed with
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carbonyl groups. One technique used was Doebner reaction and the other technique used was Claisen-Schmidt reaction. Therefore the aim of this experiment is to synthesize trans p-methoxycinnamic acid and to synthesize dibenzalacetone via an aldol condensation reaction between acetone and benzaldehyde. The products would be recrystallized using ethanol‚ then characterized using melting point analysis. Introduction: In this experiment we learnt on carbonyl compounds‚ enols and enolates. We also learnt
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ketone (1‚3-diphenyl-2-propanone) with benzil in the presence of base. The reaction then proceeded with an aldol condensation reaction.5 This product was obtained using extraction (reflux)‚ recrystallization and vacuum filtration to separate the product from the waste. Experiment Scheme: Figure 1: Experiment Reaction5 Figure 2: Step wise reaction mechanism including aldol condensation reaction5 Procedure: About 1.55-g of benzil‚ 1.51-g of dibenzylketone and 12-mL of ethanol were placed in a 50-mL
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Aldol Condensation Wei-Hsuan Tsui 4/16/14 The reaction of an aldehyde with a ketone employing sodium hydroxide as the base is an example of a mixed aldol condensation reaction‚ the Claisen-Schmidt reaction. Dibenzalacetone is readily prepared by condensation of acetone with two equivalents of benzaldehyde -26 -95 113.9 1. Weigh 0.212 g of pure benzaldehyde directly into a 10 x 100 mm reaction tube. 2.
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Shabnaz Rob 4.29.14 Aldol Condensation Introduction The purpose of this lab was to prepare dibenzalacetone (1‚5-diphenyl-1‚4-pentadiene-3-one). The preparation of dibenzalacetone is base catalyzed. It is a compound reaction that involves an aldol reaction and then dehydration. This overall reaction is known as the Clasien-Schmidt condensation. Aldol addition occurs when an aldehyde forms an aldol in equilibrium. Usually two molecules of aldehydes combine with a base two
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AIM: TO MAKE BAKELITE USING PHENOL AND FORMALDEHYDE. INDRODUCTION: WHAT IS BAKELITE? Bakelite or polyoxybenzylmethylenglycolanhydride is an early plastic. It is a thermosetting phenol formaldehyde resin‚ formed from an elimination reaction of phenol with formaldehyde. It was developed by Belgian-born chemist Leo Baekeland in New York in 1907. One of the first plastics made from synthetic components‚ Bakelite was used for its electrical non-conductivity and heat-resistant properties
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Point of Benzoin: 132°C Theoretical Melting Point of Benzil: 94.5°C Discussion and Conclusions: The purpose of this experiment was to prepare benzil by first converting benzaldehyde to benzoin by the benzoin condensation‚ then oxidizing benzoin to benzil. The benzoin condensation was carried out using thiamine hydrochloride‚ or vitamin B1‚ as a catalyst. The percent yield of the product was sub-par. It was found to be 54.4%‚ which may have been due to the formation of other byproducts during
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