Franciscan missionaries arrived in Antipolo in 1578 and built a church in Boso-Boso. In 1591 they were replaced by the Jesuits who organized the village into a parish. On March 25, 1626 Governor-General Juan Niño de Tabora brought from Acapulco, Mexico the image of the Virgin Mary. Before he died, he bequeathed the image to the Jesuits for the Antipolo Church. In 1639, the Chinese revolt reached Antipolo and burned the church down; however, the image was unharmed. It stayed in Cavite for 14 years. 10 years after the incident the image was renamed "Nuestra Señora de la Paz y Buen Viaje" (Tagalog: "Ang Mahal na Birhen ng Kapayapaan at Mabuting Paglalayag"; "Our Lady of Peace and Good Voyage"). A replica of the image of the Birhen ng Antipolo is now enshrined in the U.S. for all the immigrant Filipinos. The village of Antipolo was made into a town in 1650 as part of the Province of Tondo but then it became a province of manila. The district was later known as the District of Morong. The Recollects took over Antipolo in 1864. It was during these years that the Virgin of Antipolo gained thousands of devotees. Devotees from Manila and nearby towns and provinces flock to Antipolo on foot along mountain trails and springs.
The City was named after a tree locally known as Tipolo (Autocarpus Incisa) which was in abundance in the area at the time. It is because the image of the Virgin Mary was lost several times and each time it was recovered on a Tipolo tree.