Antithrombin III

Antithrombin III (AT III) is a glycoprotein and member of serpin super family protein .AT III inactivates more than a few enzymes of the blood coagulation system in Homo sapiens .The AT III gene on chromosome 1 encodes a glycoprotein of approximately 58 KDa MW .AT III is having 432 amino acids length with a single chain glycoprotein and 3 disulfide bridges and 4 carbohydrate side chains that report for 15% of the total mass .AT III also act as a mediator of heparin's anticoagulant activity with two to three days of biological half life [139]. Alfa AT III is also the most important form of AT III originated in blood plasma and has an oligosaccharide occupying each of its four glycosylation sites. A single glycosylation site remains always