Biochemical Parameters of Sperm Flagellar Motility Initiation and Regulation
Biochemical Parameters of Sperm Flagellar Motility Initiation and Regulation
Sudipta Saha1, Kaushik Das1, Saswati Banerjee1, Debjani Nath1, Arunima Maiti1, Madhabi Barua1, Chanakya Nath Kundu1, Mahitosh Mandal1, Jitamanyu Chakrabarty1, Bijay Shankar Jaiswal1, Debdas Bhattacharyya2, Debprasad Chattopadhyay3, Sandhya Rekha Dungdung1, Gopal Chandra Majumder*, 1, 2. *Corresponding Author E-Mail: majumdergc42@yahoo.co.in
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Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata – 700 032, India.
Centre for Rural and Cryogenic Technologies, Jadavpur University, Kolkata – 700 032, India.
ICMR Virus Unit, Infectious Diseases & Beliaghata General Hospital, General Block 4, 1st Floor, 57, Dr. Suresh Chandra Banerjee Road, Kolkata – 700 010.
Introduction Sperm cell is the male gamete and it is haploid in nature. This unique microscopic motile cell performs an important function in biology: fertilization of ova. Sperm remain alive and retain their ability to fertilize an ovum (egg) from 24-48 hours after having been released in the female genital tract. A typical mammalian sperm consists of a head, neck, middle piece and tail. Mammalian testicular spermatozoa are immotile and infertile. The male gametes undergo a hormone (testosterone) dependent maturation process in the different parts of epididymis (caput, corpus and cauda) before they acquire the capacity for forward progression and fertility (Glander, 1984; Hoskins et al., 1978; Orgebin-Crist and Tichenor, 1972; Prosad et al., 1970). Sperm forward progression is established as an interactive process between the cell and its surrounding environment. The inner core of the sperm flagella contains microtubules that serve as the basic infrastructure for the ATPdependent bending of the sperm tail. The flagellar beat kinematics, sperm morphology and surface properties are responsible for the rate of forward progression (Katz et al., 1989). There is a marked increase of intrasperm level of
Sudipta Saha1, Kaushik Das1, Saswati Banerjee1, Debjani Nath1, Arunima Maiti1, Madhabi Barua1, Chanakya Nath Kundu1, Mahitosh Mandal1, Jitamanyu Chakrabarty1, Bijay Shankar Jaiswal1, Debdas Bhattacharyya2, Debprasad Chattopadhyay3, Sandhya Rekha Dungdung1, Gopal Chandra Majumder*, 1, 2. *Corresponding Author E-Mail: majumdergc42@yahoo.co.in
1 2 3
Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata – 700 032, India.
Centre for Rural and Cryogenic Technologies, Jadavpur University, Kolkata – 700 032, India.
ICMR Virus Unit, Infectious Diseases & Beliaghata General Hospital, General Block 4, 1st Floor, 57, Dr. Suresh Chandra Banerjee Road, Kolkata – 700 010.
Introduction Sperm cell is the male gamete and it is haploid in nature. This unique microscopic motile cell performs an important function in biology: fertilization of ova. Sperm remain alive and retain their ability to fertilize an ovum (egg) from 24-48 hours after having been released in the female genital tract. A typical mammalian sperm consists of a head, neck, middle piece and tail. Mammalian testicular spermatozoa are immotile and infertile. The male gametes undergo a hormone (testosterone) dependent maturation process in the different parts of epididymis (caput, corpus and cauda) before they acquire the capacity for forward progression and fertility (Glander, 1984; Hoskins et al., 1978; Orgebin-Crist and Tichenor, 1972; Prosad et al., 1970). Sperm forward progression is established as an interactive process between the cell and its surrounding environment. The inner core of the sperm flagella contains microtubules that serve as the basic infrastructure for the ATPdependent bending of the sperm tail. The flagellar beat kinematics, sperm morphology and surface properties are responsible for the rate of forward progression (Katz et al., 1989). There is a marked increase of intrasperm level of