Biochemistry Enzymes
Action of enzymes as catalysts in biochemical processes
* Enzymes acts as catalyst and increase the rate of all the chemical reactions. * Enzymes are also described by two properties like all other catalysts. It composed of two main functions. * The first function is that, they increase the rate of chemical reactions by without consumed themselves or undergo any change or alteration in the reaction. . ( Zemitec et,al 2008). * The second function is, they increase reaction rates without changing the chemical equilibrium between the reactants and products. ( Bhagavan et,al 2006). * The reaction between two substrates are catalyzed by enzymes. The enzyme brings a template upon which the two substrates are combined together in the proper position and make them to react each other.
Deficiency in aldolase B and hereditary fructose intolerance * Hereditary fructose intolerance is a condition I which affects a humans ability to digest the fructose sugar. The incidence of hereditary fructose intolerance is 1to 2 in 20000 to 30000 individuals in a year worldwide. .( John .R.H 1996) * Hereditary fructose intolerance can be caused by mutations in the ALDOB gene. The ALDOB gene is responsible for making the aldolase B enzyme. The aldolase B enzyme is primarily seen in the Liver. This helps for the fructose metabolism. This enzyme is responsible for the further step in the metabolism of fructose, which breaks down the molecule fructose-1-phosphate into other molecules called glyceraldehyde and dihydroxyacetone phosphate. * The lack of aldolase B can results in the accumulation of fructose 1 phosphate in the liver. This seems to be toxic and can cause death of liver cells. The short of aldolase B can cause the reduction of dihydroxyacetone phosphate and this will lead to decrease in phosphate level in the body. ( Monique L 2008) * The damage of liver cells and a decrease level of phosphate groups will lead to hypoglycemia and will damage
* Enzymes acts as catalyst and increase the rate of all the chemical reactions. * Enzymes are also described by two properties like all other catalysts. It composed of two main functions. * The first function is that, they increase the rate of chemical reactions by without consumed themselves or undergo any change or alteration in the reaction. . ( Zemitec et,al 2008). * The second function is, they increase reaction rates without changing the chemical equilibrium between the reactants and products. ( Bhagavan et,al 2006). * The reaction between two substrates are catalyzed by enzymes. The enzyme brings a template upon which the two substrates are combined together in the proper position and make them to react each other.
Deficiency in aldolase B and hereditary fructose intolerance * Hereditary fructose intolerance is a condition I which affects a humans ability to digest the fructose sugar. The incidence of hereditary fructose intolerance is 1to 2 in 20000 to 30000 individuals in a year worldwide. .( John .R.H 1996) * Hereditary fructose intolerance can be caused by mutations in the ALDOB gene. The ALDOB gene is responsible for making the aldolase B enzyme. The aldolase B enzyme is primarily seen in the Liver. This helps for the fructose metabolism. This enzyme is responsible for the further step in the metabolism of fructose, which breaks down the molecule fructose-1-phosphate into other molecules called glyceraldehyde and dihydroxyacetone phosphate. * The lack of aldolase B can results in the accumulation of fructose 1 phosphate in the liver. This seems to be toxic and can cause death of liver cells. The short of aldolase B can cause the reduction of dihydroxyacetone phosphate and this will lead to decrease in phosphate level in the body. ( Monique L 2008) * The damage of liver cells and a decrease level of phosphate groups will lead to hypoglycemia and will damage
References: John R Holum, 1996, 2nd ed, organic and biological chemistry, von Hoffman press. Monique Laberge phd,2008, 1st ed, essential chemistry, Chelsea house publications. Nelson David, 2005, 1st ed, principles of biochemistry, WH freeman company. www. Wikipedia.com? Cori /cycle Lowenstein J.M, 1969, 1st ed, citric acid cycle, Boston academic publication. Bhagavan et al, 2006, 1st ed, coenzyme Q10, intake and absorption, free radical research. Zmitek et al, 2008, improving bioavailability of coq10, Agro food IND.