Biochemistry Case Studies
Biochemistry GRT 1 Task 4 -Case Studies
Marie Marks
Western Governors University
Introduction
The two case studies given both involve in the processes of making energy that the body needs to maintain and sustain life. Each case is a different diagnosis but they both have some involvement in the production of ATP and other products when creating energy. If someone has an issue with the production of energy it is hard to maintain life in the body. The body has many different enzymes that are needed to reacts with others that then create what we need in the body. Everything has their own special role and when that certain enzyme or thing is missing it affects many other things in the body.
In case study one; the patient is diagnosed with hereditary fructose intolerance with many symptoms including: loss of appetite, jaundice, kidney and liver not functioning, and generalized tremors. Hereditary fructose intolerance is when the person is lacking the enzyme that is needed to break down fructose. Enzymes are able to simplify chemical reactions, reduce energy requirements and achieve the desired results with incredible precision (http://www.sternenzym.de/english/enzymes/index.html). In enzymatic processes the risk of unintentional side reactions can be excluded almost entirely, since each enzyme fits only one substrate like a key in a lock: it only boosts the reaction to which it belongs (http://www.sternenzym.de/english/enzymes/index.html). The enzyme that is missing is called the aldolase B. When this enzyme is missing the body cannot break down fructose which then chemically alters the process of changing glycogen into glucose. Blood sugar may fail and then causes the liver to store substances that are dangerous to the body. Aldolase B is found in the liver but also in the kidneys and intestinal. Aldolase B is responsible for the second step in the metabolism of fructose, which breaks down the molecule fructose-1-phosphate into glyceraldehyde and
Marie Marks
Western Governors University
Introduction
The two case studies given both involve in the processes of making energy that the body needs to maintain and sustain life. Each case is a different diagnosis but they both have some involvement in the production of ATP and other products when creating energy. If someone has an issue with the production of energy it is hard to maintain life in the body. The body has many different enzymes that are needed to reacts with others that then create what we need in the body. Everything has their own special role and when that certain enzyme or thing is missing it affects many other things in the body.
In case study one; the patient is diagnosed with hereditary fructose intolerance with many symptoms including: loss of appetite, jaundice, kidney and liver not functioning, and generalized tremors. Hereditary fructose intolerance is when the person is lacking the enzyme that is needed to break down fructose. Enzymes are able to simplify chemical reactions, reduce energy requirements and achieve the desired results with incredible precision (http://www.sternenzym.de/english/enzymes/index.html). In enzymatic processes the risk of unintentional side reactions can be excluded almost entirely, since each enzyme fits only one substrate like a key in a lock: it only boosts the reaction to which it belongs (http://www.sternenzym.de/english/enzymes/index.html). The enzyme that is missing is called the aldolase B. When this enzyme is missing the body cannot break down fructose which then chemically alters the process of changing glycogen into glucose. Blood sugar may fail and then causes the liver to store substances that are dangerous to the body. Aldolase B is found in the liver but also in the kidneys and intestinal. Aldolase B is responsible for the second step in the metabolism of fructose, which breaks down the molecule fructose-1-phosphate into glyceraldehyde and
References: http://ghr.nlm.nih.gov/gene/ALDOB http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001399/ http://www.sternenzym.de/english/enzymes/index.html http://www.umdf.org/site/c.8qKOJ0MvF7LUG/b.7934627/k.3711/What_is_Mitochondrial_Disease.htm