Bovine Spongiform Encephalopathy
Bovine Spongiform
Encephalopathy
Tyrosine
- Chemical Properties: Aromatic
-Toxicity: when given to mice intraperitoneally, at doses
>1450mg/kg, Tyrosine is said to be toxic. In humans, prolonged exposure to Tyrosine could cause urinary system, blood and behavior problems.Prolonged skin exposure could cause dermatitis. National Fire
Protection rates health hazard of
Tyrosine a 1.
-Flammability: May be combustible at high temperatures. No available flammability limits, but the flash point is 348.8 degrees Farenheit in closed cup. National Fire Protection rates flammability of Tyrosine a 1.
(“Msds Safety data”, 2005)
Primary, Seconday, Tertiary & Quaternary
Structures
Dehydration & Hydrolysis
4 Bonds Of The Tertiary Structure
-Hydrophobic: when amino acids come together to form the interior of a molecule to repel contact with water.
-Van der Waals interacion: weak electrical bond that attracts molecules to each other.
-Ionic: the attraction between positive and negative charges in an R group.
-Disulfide bridge: strong covalent bond between two molecules.
(Wolfe, 2000)
Bovine Spongiform Encephalopathy:
Prions
-Prion:the improper folding of a protein in the brain named PrPc.
2 important properties:
-It is an infectious protein (PrPSc) that destroys nerve cells in the amyloid plaques of the brain and can lead to loss of brain function or dementia. -Has the ability to make more copies of the same misfolded protein over and over again.
(Ahern & Rajagopal,2012)
Bovine Spongiform Encephalopathy:
Chaperone Protein
-misfolding of PrPc -> PrPSc = BSE
-PrPSc passes on misfolding of prion and spreads to the PrPc which acts as the chaperone. -Cells job is to make PrPc, the PrPc gets converted to PrPSc and the chaperone cannot convert back to PrPC
(Hudon-Miller, 2012)
Bovine Spongiform Encephalopathy:
Protein Misfolding & Aggregation
-PrPSc = hydrophobic
-Proteosome = a protein destroyer.
Encephalopathy
Tyrosine
- Chemical Properties: Aromatic
-Toxicity: when given to mice intraperitoneally, at doses
>1450mg/kg, Tyrosine is said to be toxic. In humans, prolonged exposure to Tyrosine could cause urinary system, blood and behavior problems.Prolonged skin exposure could cause dermatitis. National Fire
Protection rates health hazard of
Tyrosine a 1.
-Flammability: May be combustible at high temperatures. No available flammability limits, but the flash point is 348.8 degrees Farenheit in closed cup. National Fire Protection rates flammability of Tyrosine a 1.
(“Msds Safety data”, 2005)
Primary, Seconday, Tertiary & Quaternary
Structures
Dehydration & Hydrolysis
4 Bonds Of The Tertiary Structure
-Hydrophobic: when amino acids come together to form the interior of a molecule to repel contact with water.
-Van der Waals interacion: weak electrical bond that attracts molecules to each other.
-Ionic: the attraction between positive and negative charges in an R group.
-Disulfide bridge: strong covalent bond between two molecules.
(Wolfe, 2000)
Bovine Spongiform Encephalopathy:
Prions
-Prion:the improper folding of a protein in the brain named PrPc.
2 important properties:
-It is an infectious protein (PrPSc) that destroys nerve cells in the amyloid plaques of the brain and can lead to loss of brain function or dementia. -Has the ability to make more copies of the same misfolded protein over and over again.
(Ahern & Rajagopal,2012)
Bovine Spongiform Encephalopathy:
Chaperone Protein
-misfolding of PrPc -> PrPSc = BSE
-PrPSc passes on misfolding of prion and spreads to the PrPc which acts as the chaperone. -Cells job is to make PrPc, the PrPc gets converted to PrPSc and the chaperone cannot convert back to PrPC
(Hudon-Miller, 2012)
Bovine Spongiform Encephalopathy:
Protein Misfolding & Aggregation
-PrPSc = hydrophobic
-Proteosome = a protein destroyer.