Case Study Example
HSC 4555 Spring 2015
Case Study Example
A.S. was recently diagnosed with Hodgkin disease and scheduled for a staging procedure. His previous axillary lymph node biopsy result was positive for Reed-Sternberg cells. The surgeon charted the results of the staging procedure as “stage I.”
Discussion Questions
1. What is the purpose of the staging procedure for A.S.?
Staging system establishes a correlation between anatomic extent of disease and prognosis.
Staging is used to determine the most appropriate type of treatment: local, regional, or disseminated.
2. How does Hodgkin lymphoma spread in the body, and what does “stage I” signify for A.S.?
Hodgkin disease arises in a single mutant cell located in a single node or chain of nodes and spreads characteristically to anatomically contiguous nodes.
Stage I: Involvement of a single lymph node region is associated with a high cure rate.
3. What is the difference between Hodgkin disease and non-Hodgkin lymphoma?
The primary difference between Hodgkin disease and non-Hodgkin lymphoma is the presence or absence of Reed-Sternberg cells. These large malignant cells are found in Hodgkin disease and are thought to be a type of malignant B lymphocyte.
Non-Hodgkin lymphoma also usually develops in the lymph nodes, but can originate in any lymphatic tissue or organ. It is commonly found in older adult, and in general there is a greater incidence in males than females. It is increasingly seen in AIDS patients. It involves T, B, or NK cells and has a poorer long-term survival than HD because most patients have advanced disease at the time of diagnosis. It does not spread in an orderly fashion along a lymphatic series of nodes and is not usually localized. The GI tract, liver, and bone marrow are more likely to be involved. The B symptoms of Hodgkin disease are not commonly seen.
Hodgkin disease is usually localized at a single axial group of nodes (cervical, mediastinal, paraaortic), and continuous spread along the string of
Case Study Example
A.S. was recently diagnosed with Hodgkin disease and scheduled for a staging procedure. His previous axillary lymph node biopsy result was positive for Reed-Sternberg cells. The surgeon charted the results of the staging procedure as “stage I.”
Discussion Questions
1. What is the purpose of the staging procedure for A.S.?
Staging system establishes a correlation between anatomic extent of disease and prognosis.
Staging is used to determine the most appropriate type of treatment: local, regional, or disseminated.
2. How does Hodgkin lymphoma spread in the body, and what does “stage I” signify for A.S.?
Hodgkin disease arises in a single mutant cell located in a single node or chain of nodes and spreads characteristically to anatomically contiguous nodes.
Stage I: Involvement of a single lymph node region is associated with a high cure rate.
3. What is the difference between Hodgkin disease and non-Hodgkin lymphoma?
The primary difference between Hodgkin disease and non-Hodgkin lymphoma is the presence or absence of Reed-Sternberg cells. These large malignant cells are found in Hodgkin disease and are thought to be a type of malignant B lymphocyte.
Non-Hodgkin lymphoma also usually develops in the lymph nodes, but can originate in any lymphatic tissue or organ. It is commonly found in older adult, and in general there is a greater incidence in males than females. It is increasingly seen in AIDS patients. It involves T, B, or NK cells and has a poorer long-term survival than HD because most patients have advanced disease at the time of diagnosis. It does not spread in an orderly fashion along a lymphatic series of nodes and is not usually localized. The GI tract, liver, and bone marrow are more likely to be involved. The B symptoms of Hodgkin disease are not commonly seen.
Hodgkin disease is usually localized at a single axial group of nodes (cervical, mediastinal, paraaortic), and continuous spread along the string of