Celebrex Research Paper
Celebrex is a non steroidal anti-inflammatory drug that is used to reduce ormones which cause inflammation and pain in the body. Including "arthritis, ankylosing spondylitis, hereditary polyps in the colon, and menstrual pain. It is also used to treat juvenile rheumatoid arthritis in children who are at least 2 years old." (Drugs)
Classification:
Celebrex is classified as both a therapeutic and pharmacologic drug.
Therapeutic:
Anti Rheumatics
-(Non steroidal
'Anti Inflammatory agent Pharmacologic
Cox-2 Inhibitors - (These inhibitors directly targets cyclooxygenase-2, an enzyme responsible for inflammation and pain.)
Indications:
The need for Celebrex is indicated through signs and symptoms of osteoarthritis, rheumatoid arthritis, juvenile …show more content…
This enzyme is required for the synthesis of prostaglandins which regulate hormones, inflammation, and calcium movement. This creates the analgesic, and anti-inflammatory properties
Pharmacokinetics:
Absorption: "When absorbing, the peak plasma levels of celecoxib occur approximately 3 hrs after an oral dose. Under fasting conditions, both peak plasma levels and area under the curve are roughly dose-proportional up to 200 mg twice daily; at higher doses there are less than proportional increases in plasmas levels and the curve." (Drugs) Bioavailability is still untested and unavailable
Distribution: Celebrex is a highly bound protein, 97% of it is bound to plasma proteins. It primarily binds to albumin and a little lesser to glycoproteins. This resul!,in a extensive tissue distribution at a consistent rate.
Metabolism and Excretion: Mostly metabolized by the hepatic CYP2C9 isoenzyme; the CYP2C9 enzyme system exhibits genetic polymorphism. The other two are carboxylic acid and its glucuronide conjugate. The half life of Celebrex is about 11 hours. Once at mination it has been found to mainly be excreted through the feces with a small amount of the unused drug excreted through the urine. 7 0s- t.C..7
Classification:
Celebrex is classified as both a therapeutic and pharmacologic drug.
Therapeutic:
Anti Rheumatics
-(Non steroidal
'Anti Inflammatory agent Pharmacologic
Cox-2 Inhibitors - (These inhibitors directly targets cyclooxygenase-2, an enzyme responsible for inflammation and pain.)
Indications:
The need for Celebrex is indicated through signs and symptoms of osteoarthritis, rheumatoid arthritis, juvenile …show more content…
This enzyme is required for the synthesis of prostaglandins which regulate hormones, inflammation, and calcium movement. This creates the analgesic, and anti-inflammatory properties
Pharmacokinetics:
Absorption: "When absorbing, the peak plasma levels of celecoxib occur approximately 3 hrs after an oral dose. Under fasting conditions, both peak plasma levels and area under the curve are roughly dose-proportional up to 200 mg twice daily; at higher doses there are less than proportional increases in plasmas levels and the curve." (Drugs) Bioavailability is still untested and unavailable
Distribution: Celebrex is a highly bound protein, 97% of it is bound to plasma proteins. It primarily binds to albumin and a little lesser to glycoproteins. This resul!,in a extensive tissue distribution at a consistent rate.
Metabolism and Excretion: Mostly metabolized by the hepatic CYP2C9 isoenzyme; the CYP2C9 enzyme system exhibits genetic polymorphism. The other two are carboxylic acid and its glucuronide conjugate. The half life of Celebrex is about 11 hours. Once at mination it has been found to mainly be excreted through the feces with a small amount of the unused drug excreted through the urine. 7 0s- t.C..7