Dapsone Research Paper
Dapsone, an antibacterial is primarily and effectively useful in the leprosy treatment which is also used in combination with Rifampicin and Clofazimine for the treatment of Mycobacterium leprae infections(leprosy) [1-4], malaria[5-7] and pneumocystis pneumonia(PCP) [8-10]. Specifically, Dapsone stops the bacterial dihydrofolic acid synthesis through the process of binding itself in the active site of the enzyme named 6-hydroxymethyl-7, 8-dihydropteroate synthase (DHPS), which takes part in the condensation of para-aminobenzoic acid (pABA) with 6-hydroxymethyl-7, 8-dihydropterin-pyrophosphate to form 7, 8-dihydropteroate and pyrophosphate [11]. Moreover Dapsone competes with para-aminobenzoate on the active site of DHPS and inhibits the
bacterial dihydrofolic acid synthesis [12].
Some of the works in literature studied about Dapsone such as Mendes et al carried out the geometric and electronic study of Dapsone and discussed the symmetric and asymmetric conformational isomer of the molecule [13]. Borges et al carried out the first density functional study of the Dapsone derivatives on methemoglobin[14]. Battacharya et al revisited Dapsone Photophysics in different solvent [15]. To the best of our knowledge neither the study of theoretical charge density nor interactions have been carried out in the literature.
bacterial dihydrofolic acid synthesis [12].
Some of the works in literature studied about Dapsone such as Mendes et al carried out the geometric and electronic study of Dapsone and discussed the symmetric and asymmetric conformational isomer of the molecule [13]. Borges et al carried out the first density functional study of the Dapsone derivatives on methemoglobin[14]. Battacharya et al revisited Dapsone Photophysics in different solvent [15]. To the best of our knowledge neither the study of theoretical charge density nor interactions have been carried out in the literature.