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Dd-1 Pathophysiology

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Dd-1 Pathophysiology
Cigarette smoke induces oxidative stress, which may lead to lung injury and emphysema development. The pathophysiology of this disease is not fully understood and there is a very limited effective treatment. We have discovered that DJ-1 has a cytoprotective function in alveolar type II cells. However, DJ-1 oxidation leads to its degradation, mitochondrial dysfunction and these cell injury. Targeting DJ-1 may provide potential therapeutic strategies against lung disease
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