Diagnostic Accuracy of Computed Tomographic Colonography for the Detection of Advanced Neoplasia in Individuals at Increased Risk of Colorectal Cancer
ORIGINAL CONTRIBUTION
Diagnostic Accuracy of Computed
Tomographic Colonography for the Detection of Advanced Neoplasia in Individuals at Increased Risk of Colorectal Cancer
Daniele Regge, MD
Cristiana Laudi, MD
Giovanni Galatola, MD
Patrizia Della Monica, PhD
Luigina Bonelli, MD
Giuseppe Angelelli, MD
Roberto Asnaghi, MD
Brunella Barbaro, MD
Carlo Bartolozzi, MD
Didier Bielen, MD
Luca Boni, MD
Claudia Borghi, MD
Paolo Bruzzi, MD
Maria Carla Cassinis, MD
Massimo Galia, MD
Teresa Maria Gallo, MD
Andrea Grasso, MD
Cesare Hassan, MD
Andrea Laghi, MD
Maria Cristina Martina, MD
Emanuele Neri, MD
Carlo Senore, MD
Giovanni Simonetti, MD
Silvia Venturini, MD
Giovanni Gandini, MD
C
OLORECTAL CANCER (CRC) accounts for approximately
210 000 deaths each year in
Europe. 1 The majority of
CRCs arise within adenomatous polyps,2 and polypectomy is associated with a reduction in CRC incidence and
For editorial comment see p 2498.
Context Computed tomographic (CT) colonography has been recognized as an alternative for colorectal cancer (CRC) screening in average-risk individuals, but less information is available on its performance in individuals at increased risk of CRC.
Objective To assess the accuracy of CT colonography in detecting advanced colorectal neoplasia in asymptomatic individuals at increased risk of CRC using unblinded colonoscopy as the reference standard.
Design, Setting, and Participants This was a multicenter, cross-sectional study.
Individuals at increased risk of CRC due to either family history of advanced neoplasia in first-degree relatives, personal history of colorectal adenomas, or positive results from fecal occult blood tests (FOBTs) were recruited in 11 Italian centers and 1 Belgian center between December 2004 and May 2007. Each participant underwent CT colonography followed by colonoscopy on the same day.
Main Outcome Measures Sensitivity and specificity of CT colonography in detecting individuals
Diagnostic Accuracy of Computed
Tomographic Colonography for the Detection of Advanced Neoplasia in Individuals at Increased Risk of Colorectal Cancer
Daniele Regge, MD
Cristiana Laudi, MD
Giovanni Galatola, MD
Patrizia Della Monica, PhD
Luigina Bonelli, MD
Giuseppe Angelelli, MD
Roberto Asnaghi, MD
Brunella Barbaro, MD
Carlo Bartolozzi, MD
Didier Bielen, MD
Luca Boni, MD
Claudia Borghi, MD
Paolo Bruzzi, MD
Maria Carla Cassinis, MD
Massimo Galia, MD
Teresa Maria Gallo, MD
Andrea Grasso, MD
Cesare Hassan, MD
Andrea Laghi, MD
Maria Cristina Martina, MD
Emanuele Neri, MD
Carlo Senore, MD
Giovanni Simonetti, MD
Silvia Venturini, MD
Giovanni Gandini, MD
C
OLORECTAL CANCER (CRC) accounts for approximately
210 000 deaths each year in
Europe. 1 The majority of
CRCs arise within adenomatous polyps,2 and polypectomy is associated with a reduction in CRC incidence and
For editorial comment see p 2498.
Context Computed tomographic (CT) colonography has been recognized as an alternative for colorectal cancer (CRC) screening in average-risk individuals, but less information is available on its performance in individuals at increased risk of CRC.
Objective To assess the accuracy of CT colonography in detecting advanced colorectal neoplasia in asymptomatic individuals at increased risk of CRC using unblinded colonoscopy as the reference standard.
Design, Setting, and Participants This was a multicenter, cross-sectional study.
Individuals at increased risk of CRC due to either family history of advanced neoplasia in first-degree relatives, personal history of colorectal adenomas, or positive results from fecal occult blood tests (FOBTs) were recruited in 11 Italian centers and 1 Belgian center between December 2004 and May 2007. Each participant underwent CT colonography followed by colonoscopy on the same day.
Main Outcome Measures Sensitivity and specificity of CT colonography in detecting individuals