Does Hyperthermia Cause Cell Death

In contrast, a few theories stated that hyperthermia caused cell death. Hyperthermia of 42 ◦C or slightly more leads to damage to the cells. This may include DNA damage, severe destruction of the plasma membrane and inhibition of protein synthesis with mitochondrial damage (167). However, as hyperthermia affects tumor blood vessels, the mechanism of cell damage at the cellular level is not properly understood. Temperatures at 42.5oC or higher for 1 h may damage blood vessels and lead to a decrease in blood flow at the tumor site. This may result in hypoxia, low pH and reduced nutrient supply in the tumor. Yet, mild hyperthermia at 38 - 41oC may cause an increase in blood flow (168) and improving blood circulation.
Regarding the different hyperthermia