Ebola Timeline

July 27, 1976 | Very 1st person to contract Ebola virus began to show symptoms. Ten days later he was dead | 1976 | These chemicals, the team found, target the protein encoded by the NPC1 gene identified as essential by the other research group. By binding to the NPC1 gene product in the endosome, the drug molecules appear to prevent ebola from being able to attach itself, preventing it from bursting the endosome bubble and escaping into the cell. | September 1, 1976 | Ebola-Zaire (ZEBOV)ZEBOV is even more deadly, infecting 318 people, 280 whom died. This strain of Ebola virus, killing 88% of its victims | 1989 | Ebola-Reston (REBOV)REBOV is somehow assumed not to be dangerous to humans . REBOV is the first Ebola virus to such, though it is devastating to monkeys, pigs and other animals | November 1994 | Ebola-Cote d’IvoireA female enthologist accidentally infected herself during necropsy | 2011 | Jan Carette and his colleagues track down the cellular structure targeted by ebola. The researchers used cells that they had previously infected with a form of retrovirus that inserts itself randomly into different genes, deactivating them. Nearly one million such "insertions" were mapped by the team and the cells were then challenged with a different virus carrying the outer coat of ebola. | Ebola-Sudan (SEBOV)killed 53% of its victim | The team identified the Niemann-Pick C1 (NPC1) gene as one critical entry factor as well as the members of a complex called HOPS (short for homotypic fusion and vacuole protein sorting). Both are involved in enabling small membrane-bound sacs inside cells, called endosomes, to fuse with structures called lysosomes that are involved in degrading substances within cells.