Enterococcus faecalis can cause endocarditis, bacteremia, urinary tract infections, meningitis and other infections in humans [5, 6, and 7]. Enterococcus faecalis and Enterococcus faecium are the most predominant species of clinical isolates accounting for more than 90% [8]. Enterococci …show more content…
Multidrug resistance is common among Enterococci which makes treatment problem [9, 22]. The continuous overuse or misuse of effective antibiotics has led to the ongoing emergence of new antibioticresistant pathogenic bacteria [23]. The continuous vicious cycle between rapidly increasing multidrug resistance and new drug development needs intervention. Bacteriophage therapy involves the utilization of a virus as a biocontrol agent to target and destroy disease causing bacteria and is predicted to be a practicable alternative therapy because of its long history of successful use in the eastern countries [24, 25, 26, 27, 28].
Major advancements in the field includes the specificity of the interaction, the gene networks of coevolving partners, and the relative importance of the coevolving interaction in complex communities and environments [29,30,31,32].
Phages are bacterial viruses that are extremely abundant in nature and are believed to be important in controlling bacterial populations in natural systems [33, 34, 35]. The property of self-replication, which results in increased concentrations as infection persists and the narrow host range of phage, which prevents harm to beneficial and naturally occurring micro