The cycle is completed when the virus approaches the central nervous system by the diffusion through neurons. since the environment is the best for the virus, it begins protein synthesis and RNA duplication. First, the RNA strand has to be duplicated to make a new generation of the virus. At the same time the proteins which are required to make the new virus copies are synthesized. The virus’s synthesized proteins and the new RNA strands assemble and form the new generation viruses which may leave the host cell through a budding process, forming an envelop from the host cell membrane. Eventually the copies can affect another host or affect the brain causing an abnormal behavior2.
To conclude, the virus life cycle consists of three major stages. The first stage is the entrance of the virus to the host cell, and the second stage is the diffusion from the side of entrance through neurons to the brain. The last stage is the replication of the virus and the formation of the new copies. Learning the different stages of rabies life cycle could help scientists to study the effects of the disease and precisely identify the symptoms of each stage. Also they can develop methods which can enhance the immune system to fight the infection of the disease or make the disease